100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 100% of ingredients have research evidence
A
Label Compliance Grade
What the Evidence Says
✨ AI-generated · Qwen 3.6 · grounded in 1 source
· methodology
Choline bitartrate and inositol are involved in lipid metabolism and cellular signaling. Research provides moderate evidence for their role in supporting cognitive function and metabolic health. However, overall evidence coverage for this specific formulation is limited.
AI-generated summary based on research evidence. Not medical advice.
Ingredients
Supplement Facts — Evidence Check
Within RDA (0.5× RDA)
38 studies (A:1, B:7)
Market median: 550.0mg (217 products)
29 studies (A:0, B:5)
Other Ingredients
Vegetable Cellulose
Calcium Silicate
Stearic Acid
Croscarmellose
Vegetable Magnesium Stearate
Vegetable Cellulose Coating
Claims
Label Claims — Verification
Unverified
All Other
Unverified
Structure/Function
Info
Product Information
Directions for Use
DIRECTIONS: For adults, take one (1) to five (5) caplets daily, preferably with meals.
Warnings & Precautions
WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Store in a cool, dry place. Do not use if seal under cap is broken or missing.
Formulation Notes
No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
Vegetarian Dietary Supplement
Additional Information
500MG
PROD. #4280 B4280 03D
Essential for Brain Function*
Vitamin World products are subject to critically stringent quality assurance analysis. Our state-of-the-art laboratory, manufacturing and packaging facilities insure the highest quality nutritional supplements money can buy. Your health & safety are our first priority!
QUALITY ASSURED
Get healthy.
Metadata
Product Details
UPC / SKU0 74312 74280 4
DSLD Entry Date2011-10-26
Product TypeVitamin
FormUnknown
Data Updated2026-04-11
Research
Research Evidence
B
Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis
Biological psychiatry. Cognitive neuroscience and neuroimaging
2024
PubMed
DOI
B
Integrating multi-structure covalent docking with machine-learning consensus scoring enhances potency ranking of human acetylcholinesterase inhibitors.
Guideline
Briefings in bioinformatics
2026
PubMed
DOI
B
Evidence-based clinical practice guidelines for functional dyspepsia 2021.
Guideline
Journal of gastroenterology
2022
PubMed
DOI
B
Scientific Opinion on health claims related to choline
Regulatory Source
EFSA Journal
2011
DOI
C
Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials
Meta Analysis
Nutrition reviews
2022
PubMed
DOI
C
Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct
The American journal of clinical nutrition
PubMed
DOI
C
Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct
The American journal of clinical nutrition
PubMed
DOI
C
Nutrient-based therapies for bipolar disorder: a systematic review
Systematic Review
Psychotherapy and psychosomatics
2013
PubMed
DOI
C
The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people
Rct
The British journal of nutrition
2007
PubMed
C
Differential metabolism of choline supplements in adult volunteers.
View all evidence for Choline →
This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.
