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Vitamin B-12 500 mg Supplement

product on market Tablet or Pill Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin B12 is essential for nerve function and the production of red blood cells. There is strong evidence supporting its role in preventing megaloblastic anemia and supporting cognitive health. This supplement provides a concentrated dose of this water-soluble vitamin.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Vitamin B-12 500 mg Supplement
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mcg (8333% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Dibasic Calcium Phosphate Cellulose Gel Stearic Acid Croscarmellose Sodium Magnesium Stearate Cyanocobalamin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

SUGGESTED USE: Take one tablet daily with a meal.

Warnings & Precautions

Do not use if imprinted seal under cap is broken or missing.

Store in a cool, dry place, out of reach of children.

Formulation Notes

No Artificial Colors - No Artificial Flavors - No Preservatives No Chemical Solvents, Yeast, Starch or Gluten

Additional Information

Supplement ITEM # 201299

List No. 1721 L31AA Cat. 573 5A005

Recommended By Pharmacists

DIETARY SUPPLEMENT USP VERIFIED(TM)

ENTER CODE WELLNESS REWARDS CODE VISIT OUR WEBSITE & EARN FREE VITAMINS www.NatureMade.com - 1-800-276-2878

ESSENTIAL FOR A HEALTHY NERVOUS SYSTEM, VITAL FOR RED BLOOD CELL FORMATION - Vitamin B-12 also promotes maintenance and growth of tissue and helps maintain nerve cells.

USP has tested and verified ingredients, product and manufacturing process. USP sets official standards for dietary supplements. See: www.usp-dsvp.org. Valid only for U.S. and Puerto Rico residents. Lot.: Exp.:

Metadata

Product Details

UPC / SKU0 31604 01721 7
DSLD Entry Date2012-06-25
Product TypeVitamin
FormTablet or Pill
BrandNature Made
DSLD ID9186
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.