🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mcg (8333% DV)
📊 208.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.5mg

Other Ingredients

Dibasic Calcium Phosphate Cellulose Gel Stearic Acid Croscarmellose Sodium Magnesium Stearate Cyanocobalamin

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

SUGGESTED USE: Take one tablet daily with a meal.

⚠️ Warnings & Precautions

Do not use if imprinted seal under cap is broken or missing.

Store in a cool, dry place, out of reach of children.

🧪 Formulation Notes

No Artificial Colors - No Artificial Flavors - No Preservatives No Chemical Solvents, Yeast, Starch or Gluten

Additional Information

Supplement ITEM # 201299

List No. 1721 L31AA Cat. 573 5A005

Recommended By Pharmacists

DIETARY SUPPLEMENT USP VERIFIED(TM)

ENTER CODE WELLNESS REWARDS CODE VISIT OUR WEBSITE & EARN FREE VITAMINS www.NatureMade.com - 1-800-276-2878

ESSENTIAL FOR A HEALTHY NERVOUS SYSTEM, VITAL FOR RED BLOOD CELL FORMATION - Vitamin B-12 also promotes maintenance and growth of tissue and helps maintain nerve cells.

USP has tested and verified ingredients, product and manufacturing process. USP sets official standards for dietary supplements. See: www.usp-dsvp.org. Valid only for U.S. and Puerto Rico residents. Lot.: Exp.:

Product Details

UPC / SKU 0 31604 01721 7
DSLD Entry Date 2012-06-25
Product Type Vitamin
Form Tablet or Pill
Brand Nature Made
DSLD ID 9186
Data Updated 2026-04-11

Research Evidence

237 Research Sources
53 Avg Quality Score
83 Meta Analysis
74 Systematic Review
45 Rct
29 Clinical Trial
2 Guideline
2 Regulatory Source
1 Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023
View all evidence for Vitamin B12 →

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