MSM & Glucosamine by Natrol — Ingredients, Evidence & Safety

Product Label

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Label Data

2 Capsule(s) Serving Size

90 Servings

Non-Nutrient/Non-Botanical Product Type

50% Evidence Coverage

Supplement Facts — Evidence Check

MSM

500 mg

📊 Market median: 1000.0mg (2 products)

This product: 500mg

Glucosamine Sulfate

500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 500mg

Other Ingredients

Gelatin Magnesium Stearate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take 2 capsules three times daily with meals.

⚠️ Warnings & Precautions

Keep out of reach of children.

Warning: This product is derived from and/or contains shellfish.

Do not take this product if you are pregnant or lactating.

🧪 Formulation Notes

No yeast, wheat, corn, milk, egg, soy, glutens, artificial colors or flavors, added sugar, starch or preservatives.

Additional Information

MSM (Methyl Sulfonyl Methane) and Glucosamine Sulfate are the subject of research on connective tissue and joint health. MSM is a compound rich in sulfur–a crucial component of the tissues. Glucosamine is a building block of cartilage. Now, Natrol combines these two compounds in one easy-to-take capsule.

Store in a cool, dry place.

3112

Promote joint comfort Promotes healthy connective tissue

Product Details

UPC / SKU 0 47469 00986 1

DSLD Entry Date 2017-12-22

Product Type Non-Nutrient/Non-Botanical

Form Capsule

Brand Natrol

DSLD ID 77618

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →