🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
Amino acid/Protein Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

50 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 50mg

Other Ingredients

Cellulose Gelatin Water Silica Magnesium Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take 1 capsule, up to four times daily, with food.

⚠️ Warnings & Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition or are taking prescription drugs including drugs for depression, migraines, Parkinson’s disease or psychiatric disorders. Do not use with other supplements containing L-tryptophan or 5-HTP. Do not use if you are pregnant, lactating or under the age of 18 years.

Do not use if you are pregnant, lactating or under the age of 18 years.

Keep out of reach of children.

🧪 Formulation Notes

Natrol 5-HTP is a drug-free plant-derived source of an amino acid that naturally increases the body’s level of serotonin, the chemical messenger that affects emotions, behavior, appetite, thought and sleep.

Naturally drug free

No yeast, wheat, corn, milk, egg, soy, glutens, artificial colors or flavors, added sugar, starch or preservatives

Additional Information

Regular use of Natrol 5-HTP helps provide a more positive outlook, and promotes relaxation, calm and greater appetite control.

Store in a cool, dry place.

ITEM: 883 F: 3000285 L: 2005337-9141

Actual size Promotes positive mood Helps control appetite

Product Details

UPC / SKU 0 47469 00883 3
DSLD Entry Date 2017-12-22
Product Type Amino acid/Protein
Form Capsule
Brand Natrol
DSLD ID 77547
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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