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  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

The safety score is low because the amount of niacin in this product is more than 14 times the recommended maximum daily limit.

Label Data

1 Tablet(s) Serving Size
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (2500% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg

Other Ingredients

Hypromellose Hydrogenated Vegetable Oil Silicon Dioxide Magnesium Stearate Glyceryl Behenate Red 40

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: Adults - one Slo-Niacin tablet morning or evening, or as directed by a physician. Before using 500 mg daily or more, consult a physician. Note: Slo-Niacin tablets may be broken on the score line, but should not be crushed or chewed.

Suggested Use Slo-Niacin is a member of the vitamin B-complex group (nicotinic acid, vitamin B3) and is suggested as a dietary supplement. This product has the advantage of a slower release of niacin than conventional dosage forms. This may permit its use by those who do not tolerate immediate-release tablets.

Directions 250 mg: Adults — one Slo-Niacin Tablet morning or evening, or as directed by a physician. 500 mg: Adults — one Slo-Niacin Tablet morning or evening, or as directed by a physician. 750 mg: Adults — one Slo-Niacin Tablet morning or evening, or as directed by a physician.

Note: Slo-Niacin tablets may be broken on the score line, but should not be crushed or chewed.

⚠️ Warnings & Precautions

Caution Niacin may cause temporary flushing, itching and tingling, feelings of warmth and headache, particularly when beginning, increasing the amount or changing brand of niacin. These effects seldom require discontinuing niacin use. Skin rash, upset stomach, and low blood pressure when standing are less common symptoms, if they persist, contact a physician.

Warnings Slo-Niacin tablets should not be used by persons with a known sensitivity or allergy to niacin.

Persons with heart disease, particularly those who have recurrent chest pain (angina) or who recently suffered a heart attack, should take niacin only under the supervision of a physician. Persons taking high blood pressure or cholesterol-lowering drugs should contact a physician before taking niacin because of possible interactions. Case reports of myopathy (unexplained muscle related complaints, including discomfort, weakness, or tenderness) have been documented with the use of HMG-CoA Reductase Inhibitors in combination with lipid-altering doses of niacin therapy (=1 gram of niacin per day).

Do not take niacin unless recommended by and taken under the supervision of a physician if you have any of the following conditions: gallbladder disease, gout, arterial bleeding, glaucoma, diabetes, impaired liver function, peptic ulcer, pregnancy or lactating women.

Increased uric acid and glucose levels and abnormal liver function tests have been reported in persons taking daily doses of 500 mg or more of niacin.

Discontinue use and consult a physician immediately if any of the following symptoms occur: persistent flu-like symptoms (nausea, vomiting, a general “not well” feeling); loss of appetite; a decrease in urine output associated with dark-colored urine; muscle discomfort such as tender, swollen muscles or muscle weakness; irregular heartbeat; or cloudy or blurry vision.

Keep out of reach of children.

Before using 500 mg daily or more, consult a physician.

🧪 Formulation Notes

Slo-Niacin 500 mg

Contains a doctor-recommended form of niacin

Contains a doctor recommended form or niacin-nicotinic acid

500 mg niacin (nicotinic acid), supplying 2,500% of the Daily Value (DV) for niacin.

Each tablet also contains: hypromellose, hydrogenated vegetable oil, silicon dioxide, magnesium stearate, glyceryl behenate, Red 40.

Additional Information

Unique polygel system designed to minimize flushing

Clinically proven to support good cholesterol (HDL)

#1 Pharmacist Recommended 2013-2014 U.S.News & World Report Pharmacy Times

Controlled release to reduce flushing

This exclusive technology ensures the gradual and measured release of niacin (nicotinic acid, a form of vitamin B3) and is designed to reduce the incidence of flushing and itching commonly associated with niacin use.

Store at controlled room temperature, 15-30(0)C (59-86(0)F). Keep tightly closed.

107699-02 R0513

Helps maintain good cholesterol (HDL) within the normal range

Unique polygel system designed to minimize flushing

1. Data on file. Upsher-Smith Laboratories, Inc. 2. Slo-Niacin (product information). Minneapolis, MN: Upsher-Smith Laboratories, Inc; 2011.

105186-03 08

250, 500, and 750 mg

Ingredients 250 mg niacin (nicotinic acid), supplying 1,250% of the Daily Value (DV) for niacin.

750 mg niacin (nicotinic acid), supplying 3,750% of the Daily Value (DV) for niacin.

105186-03 Revised 0614

Product Details

UPC / SKU 3 0245-0063-11 7
DSLD Entry Date 2017-05-24
Product Type Vitamin
Form Tablet or Pill
Brand Upsher-Smith
DSLD ID 73591
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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