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Comfort, Function & Flexibility

product on market Capsule GNC TriFlex Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Turmeric root extract and palmitic acid monoethanolamide are used to support joint comfort and flexibility. Research providing evidence for these specific ingredients is limited. The formulation focuses on managing joint function through a blend of botanical extracts and specialized lipids.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Comfort, Function & Flexibility
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Yellow Capsule(s)
Serving Size
Other Combinations
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Levagen Palmitic Acid Monoethanolamide
300 mg
Joint Comfort Proprietary Blend
250 mg
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)

Other Ingredients

Cellulose Gelatin Magnesium Stearate Polysorbate 80 Povidone Stearic Acid
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take the contents of one pack daily.

Warnings & Precautions

Warning: Do not use if pregnant, nursing or allergic or contraindicated to aspirin. If you are taking aspirin or blood thinning or other medication, or have a medical condition, consult your physician before using this product.

Warning: Do not use if pregnant, nursing or allergic or contraindicated to aspirin. If you are taking aspirin or blood thinning or other medication, or have a medical condition, consult your physician before using this product.

Discontinue use two weeks prior to surgery.

Formulation Notes

No sugar, no artificial colors, no artificial flavors, no preservatives, no wheat, gluten free, no dairy, yeast free.

With four powerful, clinically studied ingredients, TriFlex Daily Pack is our most comprehensive program to support improved joint comfort, flexibility and function. It includes: Comfort, Function & Flexibility support - Features a blend of natural plant extracts that is clinically shown to provide 30% improvement in flexibility and 19% improvement in joint function in as few as 30 days. Plus it contains Levagen, which is clinically studied to support the body's natural anti-inflammatory response. Also includes turmeric.

Provides clinical-strength doses of our joint comfort blend, Levagen, glucosamine and chondroitin - plus EPA

Additional Information

Gf Gluten free

Comfort, Function & Flexibility

Store in a cool, dry place.

Our quality commitment to you Since 1935, our mission has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find you a replacement product that is right for you.

In a 12 week multi-center, randomized, double-blind, placebo-controlled study of 60 adults, subjects taking 250 mg/day of the Joint Comfort Proprietary Blend showed a significant 29.8% improvement in joint flexibility and a 19.4% improvement in joint function in 30 days compared to subjects on placebo.

New!

Promotes joint health

Comprehensive program with clinically proven ingredients Supports improved joint comfort, flexibility and function, and the body's natural anti-inflammatory response

CODE 303212 LQG

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

Actual size

Metadata

Product Details

DSLD Entry Date2017-01-25
Product TypeOther Combinations
FormCapsule
DSLD ID69625
Data Updated2026-04-11
Research

Research Evidence

311
Research Sources
54
Avg Quality
121
Systematic Review
98
Meta Analysis
70
Rct
16
Clinical Trial
2
Other
1
Narrative Review
1
Openfda Safety
A The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis
Meta Analysis Bioscience reports 2021 PubMed DOI
B Curcumin for depression: a meta-analysis
Meta Analysis Critical reviews in food science and nutrition 2020 PubMed DOI
B Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2024 PubMed DOI
B Complementary and Alternative Medicine Therapies for Psoriasis: A Systematic Review
Meta Analysis JAMA dermatology 2018 PubMed DOI
B Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review
Systematic Review Critical reviews in food science and nutrition 2022 PubMed DOI
B Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2024 PubMed DOI
B The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis
Meta Analysis Complementary therapies in medicine 2021 PubMed DOI
B Efficacy of Curcumin-Mediated Antimicrobial Photodynamic Therapy on Candida spp.-A Systematic Review
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B Natural Products in Alzheimer's Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms
Systematic Review International journal of molecular sciences 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.