🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Caplet(s) Serving Size
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 400mg

Other Ingredients

Vegetable Cellulose Polymethacrylate Contains 2% of

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (79% of products) Nutrient (9% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: For adults, take one (1) caplet three times daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal.

⚠️ Warnings & Precautions

Keep out of reach of children.

Do not use if blister seal is cut, torn or open.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

🧪 Formulation Notes

No Artificial Flavor, No Preservatives, No Sugar, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish.

Additional Information

Store at room temperature.

Item # 13185 B36222 06C

Part No. 22-13186

Supports mood & emotional well-being* Promotes healthy joint function & comfort*

SAM-e is a revolutionary supplement. Because of its popularity and use, it has received widespread exposure in the press. Information has appeared in newspapers, magazines, on the Internet, or simply through word of mouth. Whether you’re a first-time SAM-e user, or have been a fan for years, you probably have some questions. Please see the enclosed package insert for more information.

All living things contain SAM-e (S-adenosylmethionine). The body makes SAM-e from the amino acid methionine. However, you may not be able to obtain sufficient methionine levels simply by ingesting food. In addition, because of age or other factors, levels of SAM-e can fluctuate or decline. Supplementation with SAM-e is the easiest way to increase intake.

SAM-e is involved in over 35 biochemical reactions involving enzymatic transmethylation.* The methylation process is the mechanism by which the body rids itself of unwanted compounds, synthesizes neurotransmitters, nourishes cartilage, regulates enzyme activity within the cell and helps maintain the flexibility of cell membranes.* Science has been looking into this remarkable supplement and have found, SAM-e: ~ Supports mood and emotional well-being* ~ Promotes healthy joint function and comfort*

SAM-e (S-adenosylmethionine) was discovered in Italy in 1952. The subject of extensive studies, SAM-e has been used in Europe since 1975. It was one of Europe’s best kept secrets until recently, when it became available in the U.S. SAM-e helps promote a positive mood and emotional well-being.* A note about our enteric coating: The enteric coating helps the breakdown of SAM-e occur in the small intestine. In addition, the enteric coating is designed to protect SAM-e from moisture and serve as a protective barrier so that SAM-e can be absorbed where it can provide you with the greatest benefits.

Product Details

UPC / SKU 0 25077 13185 3
DSLD Entry Date 2016-11-21
Product Type Non-Nutrient/Non-Botanical
Form Other (e.g. tea bag)
DSLD ID 67000
Data Updated 2026-04-11

Research Evidence

14 Research Sources
50 Avg Quality Score
8 Rct
4 Meta Analysis
2 Clinical Trial
B The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis International journal of molecular sciences 2023
B A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Rct African health sciences 2019
C The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Rct Complementary therapies in medicine 2020
C Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
Meta Analysis Phytotherapy research : PTR 2023
C Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
Meta Analysis Journal of ethnopharmacology 2016
C Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
Meta Analysis Phytotherapy research : PTR 2020
C Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
Rct Current drug research reviews 2025
C Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
Rct Chinese journal of integrative medicine 2008
C Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
Clinical Trial ClinicalTrials.gov 2025
C Fenugreek bread: a treatment for diabetes mellitus
Rct Journal of medicinal food 2009
View all evidence for Fenugreek →

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