🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 60% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

4 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
60% Evidence Coverage

Supplement Facts — Evidence Check

200 mcg (167% DV)
📊 5.7× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.2mg
📊 Market median: 300.0mg (122 products) 📚 22 studies (Tier A: 0, B: 7)
This product: 300mg
Cordyceps
1000 mg
1000 mg
📊 Market median: 1500.0mg (104 products) 📚 21 studies (Tier A: 0, B: 2)
This product: 1000mg
ATPro Matrix
800 mg

Other Ingredients

Gelatin

Label Claims — Verification

Nutrient
All Other
All Other (98% of products) Structure/Function (81% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Dosage recommendations: Take 4 capsules daily with a meal.

FOR BEST RESULTS: use OptygenHP during all intense training blocks. Optygen should be used consistently for many months. If you start taking Optygen a week before a race, benefits will be minimal. Use 1st Endurance's Ultragen(TM) for optimal recovery.

Additional Information

STORE IN A COOL DRY PLACE

• Strongest Optygen Formula Available • Improves Endurance & Performance • Enhances Oxygen Utilization • Boosts Strength & Exercise Capacity

1. Hill et al (2006); Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. 2. Kim et al. The effect of a supplement a supplement beta-alanine on muscle carnosine synthesis and excercise capacity, during 12 wk combined endurance and weight training. 3. Bucci LR; Selected herbals and human exercise performance. Am J Clin Nutr. 2000 Aug 72(2). 4. Xu J. Et al; Oxygen transfer characteristics of Rhodiola. Chin J Biotechnol 1998; 14

Covered by Albion international, Inc., U.S. Patent 5,614,553.

For a complete research packet go to www.firstendurance.com/optygen

Made in the USA

NEW & IMPROVED

This new and improved OptygenHP formula is the strongest Optygen formula available. It contains Rhodiola that's twice as strong as the original OptygenHP formula. OptygenHP also contains Beta-Alanine because clinical research has shown it increases exercise capacity and muscular strength(1,2). The two main adaptogens in OptygenHP (Rhodiola and Cordyceps CS-4) were first used by Tibetan Sherpas to help them climb Mt. Everest. Optygen and OptygenHP utilize these two unique adaptogens because clinical research on elite endurance athletes has shown them to: • Improve Performance (3) • Increase the body's ability to adopt to high levels of physical stress (3) • Increase aerobic threshold and reduce lactic acid (4)

36682010.1

Product Details

UPC / SKU 0 00000 82010 3
DSLD Entry Date 2014-02-26
Product Type Other Combinations
Form Capsule
DSLD ID 6649
Data Updated 2026-04-11

Research Evidence

212 Research Sources
54 Avg Quality Score
102 Meta Analysis
79 Systematic Review
19 Rct
3 Narrative Review
3 Regulatory Source
2 Other
2 Clinical Trial
1 Openfda Safety
A 1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis
Meta Analysis Lancet (London, England) 2016
B Interventions for preventing weight gain after smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2021
B Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence
Systematic Review Journal of exposure science & environmental epidemiology 2025
B Effects of cobalt-chromium everolimus eluting stents or bare metal stent on fatal and non-fatal cardiovascular events: patient level meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2014
B Chromium picolinate supplementation for overweight or obese adults
Meta Analysis The Cochrane database of systematic reviews 2013
B Metalloestrogens exposure and risk of gestational diabetes mellitus: Evidence emerging from the systematic review and meta-analysis
Meta Analysis Environmental research 2024
B Trace elements in schizophrenia: a systematic review and meta-analysis of 39 studies (N = 5151 participants)
Meta Analysis Nutrition reviews 2020
B A meta-analysis of heavy metals pollution in farmland and urban soils in China over the past 20 years
Meta Analysis Journal of environmental sciences (China) 2021
B The spatiotemporal variation in heavy metals in China's farmland soil over the past 20 years: A meta-analysis
Meta Analysis The Science of the total environment 2022
B Human health risk assessment from potentially toxic elements in the soils of Sudan: A meta-analysis
Meta Analysis The Science of the total environment 2025
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