Silymarin 100 mg by Life Extension — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Vegetarian Capsule(s) Serving Size

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Silymarin

100 mg

📊 Market median: 250.0mg (562 products) 📚 53 studies (Tier A: 0, B: 19)

This product: 100mg

Citrus Bioflavonoid Complex

25 mg

📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)

This product: 25mg

Other Ingredients

Microcrystalline Cellulose Vegetable Cellulose Silica Vegetable Stearate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (4% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) capsule one to three times daily with or without food, or as recommended by a healthcare practitioner.

⚠️ Warnings & Precautions

WARNINGS: KEEP OUT OF REACH OF CHILDREN.

DO NOT EXCEED RECOMMENDED DOSE.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Additional Information

Store tightly closed in a cool, dry place.

Q01684C

Supports a Healthy Liver

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Scan for product info

Do not purchase if outer seal is broken or damaged.

Q01684C

Product Details

UPC / SKU 7 37870 16845 4

DSLD Entry Date 2016-05-22

Product Type Non-Nutrient/Non-Botanical

Form Capsule

Brand Life Extension

DSLD ID 59213

Data Updated 2026-04-11

Research Evidence

69 Research Sources

55 Avg Quality Score

34 Meta Analysis

26 Systematic Review

5 Rct

3 Clinical Trial

1 Openfda Safety

A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI Cochrane

B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis

Meta Analysis Japan journal of nursing science : JJNS 2024

PubMed DOI

B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications

Meta Analysis Asia Pacific journal of clinical nutrition 2025

PubMed DOI

B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases

Meta Analysis The Cochrane database of systematic reviews 2007

PubMed

B Pharmacotherapy for trichotillomania

Meta Analysis The Cochrane database of systematic reviews 2021

PubMed DOI

B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2022

PubMed DOI

B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review

Meta Analysis Medicine 2024

PubMed DOI

B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury

Meta Analysis BMC complementary medicine and therapies 2025

PubMed DOI

B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis

Meta Analysis Medicine 2020

PubMed DOI

B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis

Meta Analysis Annals of hepatology 2024

PubMed DOI

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