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TMG Powder

product on market Powder Life Extension Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for TMG Powder
Open Full PDF View on NIH DSLD →
Details

Label Data

0.515 Gram(s)
Serving Size
97
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

None
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Read the entire label and follow directions carefully prior to use. DIRECTIONS: Take one (1) rounded scoop one to two times daily with or without food, or as recommended by a healthcare practitioner. TMG should be taken with co-factors vitamins B6, B12, and folic acid.

Warnings & Precautions

CAUTION: If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside.

WARNINGS:~ KEEP OUT OF REACH OF CHILDREN.

DO NOT EXCEED RECOMMENDED DOSE.~ Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Formulation Notes

(Trimethylglycine)

Additional Information

Q00349D

Scan for product info

Store tightly closed in a cool, dry place.

Promotes Healthy Homocysteine Levels

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Density may vary from lot to lot.

Metadata

Product Details

UPC / SKU7 37870 34905 1
DSLD Entry Date2016-04-22
Product TypeNon-Nutrient/Non-Botanical
FormPowder
BrandLife Extension
DSLD ID58667
Data Updated2026-04-11
Research

Research Evidence

23
Research Sources
47
Avg Quality
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016 PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023 PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019 PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009 PubMed DOI
View all evidence for Betaine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.