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MSM & Glucosamine Sulfate

product on market Capsule Natural Factors Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Glucosamine sulfate and MSM are commonly used to support joint health and cartilage function. Research indicates a moderate level of evidence for their effectiveness in reducing joint discomfort. These ingredients are generally well-tolerated with a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for MSM & Glucosamine Sulfate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 1000.0mg (2 products)
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)

Other Ingredients

Gelatin capsule Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested usage: 1 capsule 2–4 times per day or as directed by a health professional.

Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Contains shellfish (shrimp and crab).

Formulation Notes

MSM & Glucosamine Sulfate is a blend of naturally sourced compounds that work together to maintain healthy joints.*

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, salt, tree nuts, or GMOs.

Contains shellfish (shrimp and crab).

NON-GMO

Additional Information

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

For freshness, store in a cool, dry place.

Product of Canada

Purity&Potency Guaranteed

Recyclable container and label.

Helps maintain structural integrity of joints and connective tissue

R5

OptiMSM

isura

MASS SPEC Documentation Lab Tested

Metadata

Product Details

UPC / SKU0 68958 02698 5
DSLD Entry Date2015-10-22
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID51632
Data Updated2026-04-11
Research

Research Evidence

39
Research Sources
50
Avg Quality
20
Rct
9
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Regulatory Source
1
Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006 PubMed
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023 PubMed DOI
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009 DOI
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016 PubMed DOI
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.