🟢 90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 43% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Tablet(s) Serving Size
40 Servings
Other Combinations Product Type
43% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 {Calories}
Total Carbohydrates
2 Gram(s) (1% DV)
2000 IU (500% DV)
📊 3.3× RDA — above typical dose (UL: 0.1 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.05mg UL 0.1mg
Sodium
20 mg (1% DV)
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
Proprietary Blend
325 mg
📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)
This product: 50mg

Other Ingredients

Cellulose Stearic Acid Croscarmellose Sodium Polyvinyl Alcohol Titanium Dioxide Magnesium Stearate Talc Artificial colors PEG

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take up to two (2) tablets daily after meals or as directed by your healthcare provider. Do not exceed recommended dosage. Individual results may vary.

⚠️ Warnings & Precautions

Warning: Consult a healthcare provider prior to use if: pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains shellfish (shrimp, crab, crayfish) ingredients.

WARNING:IF YOU ARE DIABETIC, CONSULT YOUR PHYSICIAN BEFORE USING THIS PRODUCT.

If you have a Shellfish allergy please consult your physician before using this product.

🧪 Formulation Notes

No added Sugar, Artificial Flavors or Preservatives. Gluten Free.

ADVANCED TRIPLE STRENGTH + VITAMIN D3

Contains shellfish (shrimp, crab, crayfish) ingredients.

Plus the added Vitamin D3 supports bone strength and your immune system.

Additional Information

Store at room temperature.

GUARANTEED QUALITY LABORATORY TESTED

501191-1014

+Osteo Bi-Flex(R) Triple Strength+D is a registered trademark of Rexall Sundown, Inc., Boca Raton, FL 33487 USA

Many recent scientific studies have shown the effectiveness of taking supplements with the proper combination of Glucosamine HCI and Chondroitin Sulfate.* Theses compounds found in the soft cartilage, tendons and synovial fluid, are essential to the healthy functioning of tendons and joints, especially with advancing age.* Glucosamine & Chondroitin Complex Triple Strength + Vitamin D3 combines there two nutritional elements in the proper amounts for your effective use.*

2 PER DAY

Product Details

UPC / SKU 7 40985 27707 2
DSLD Entry Date 2015-03-25
Product Type Other Combinations
Form Tablet or Pill
Brand 21st Century
DSLD ID 43632
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

Compare Similar Products

View all Glucosamine products →