🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
Single Vitamin and Mineral Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

600 IU (150% DV)
✅ Within RDA (1.0× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.015000000000000001mg UL 0.1mg
Calcium
500 mg (50% DV)

Other Ingredients

Croscarmellose Sodium Cellulose Polyvinyl Alcohol Titanium Dioxide Stearic Acid PEG Talc Magnesium Stearate

Label Claims — Verification

Nutrient
All Other
Approved Health
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (54% of products) Approved Health (3% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: As a calcium supplement, take one (1) tablet twice daily with any meal or as directed by your healthcare provider.

⚠️ Warnings & Precautions

Contains a shellfish ingredient (oyster shell).

Warning: Consult a healthcare provider prior to use if: pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Do not exceed recommended dosage.

🧪 Formulation Notes

500mg Calcium 600 IU Vitamin D3

Contains a shellfish ingredient (oyster shell).

Vitamin D3 is added to assist with Calcium absorption and as support for immune function.*

No added Sugar, Yeast, Preservatives or Artificial Flavors.

Calcium 500 + D3 PLUS EXTRA D3

Additional Information

- Support for Bone Health - Easy to Swallow

LABORATORY TESTED GUARANTEED QUALITY

501078-0314

Calcium is an important mineral for supporting bone health.* Calcium also works to support muscle and nerve function.*

Adequate Calcium and Vitamin D3 as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis in later life.

Store at room temperature.

Individual results may vary.

Product Details

UPC / SKU 7 40985 27521 4
DSLD Entry Date 2015-03-25
Product Type Single Vitamin and Mineral
Form Tablet or Pill
Brand 21st Century
DSLD ID 43591
Data Updated 2026-04-11

Research Evidence

849 Research Sources
56 Avg Quality Score
450 Meta Analysis
152 Rct
137 Systematic Review
73 Clinical Trial
11 Regulatory Source
7 Other
7 Guideline
3 Openfda Safety
2 Cochrane Review
2 Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021
View all evidence for Electrolytes →

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