🟢 90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 25% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Capsule(s) Serving Size
Botanical with Nutrients Product Type
25% Evidence Coverage

Supplement Facts — Evidence Check

Proprietary Phase 1 Enzyme Blend
96 mg
Proprietary Phase 2 Enzyme Blend
70 mg
Proprietary Herbal Blend
150 mg
44 mg
📊 Market median: 100.0mg (1 products) 📚 42 studies (Tier A: 1, B: 15)
This product: 44mg

Other Ingredients

Vegetable Cellulose

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (83% of products) Nutrient (55% of products) Approved Health (6% of products) Qualified Health (3% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Recommended Adult Use: Take one capsule before each meal.

⚠️ Warnings & Precautions

WARNING: If you are pregnant, nursing, taking medication, have a health condition, or are planning a medical procedure, consult your health professional before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Do not use if inner seal is missing or broken.

Keep out of reach of children.

Additional Information

GI-ZYME

GI-Zyme capsules can help improve the level of digestion and may help ensure maximum levels of nutrient absorption.*

M(SM)

Keep bottle tightly closed.

DIGESTIVE ENZYME

SUPPORTS DIGESTIVE ABSORPTION*

Store in a cool, dry place.

Product Number 13201 US.13201.24.006

Product Details

DSLD Entry Date 2014-06-25
Product Type Botanical with Nutrients
Form Capsule
Brand Mannatech
DSLD ID 34835
Data Updated 2026-04-11

Research Evidence

120 Research Sources
51 Avg Quality Score
47 Clinical Trial
38 Rct
20 Meta Analysis
13 Systematic Review
2 Cochrane Review
A The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies
Systematic Review International journal of molecular sciences 2022
A Prebiotics for induction and maintenance of remission in ulcerative colitis
Systematic Review The Cochrane database of systematic reviews 2024
A Effect of chicory-derived inulin-type fructans on abundance of Bifidobacterium and on bowel function: a systematic review with meta-analyses
Meta Analysis Critical reviews in food science and nutrition 2023
A Probiotics for management of functional abdominal pain disorders in children
Meta Analysis The Cochrane database of systematic reviews 2023
A Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis
Meta Analysis The American journal of clinical nutrition 2018
B Effect of psyllium (Plantago ovata) fiber on LDL cholesterol and alternative lipid targets, non-HDL cholesterol and apolipoprotein B: a systematic review and meta-analysis of randomized controlled trials
Meta Analysis The American journal of clinical nutrition 2018
B Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis
Meta Analysis Neuroscience and biobehavioral reviews 2021
B Prebiotics, probiotics, fermented foods and cognitive outcomes: A meta-analysis of randomized controlled trials
Meta Analysis Neuroscience and biobehavioral reviews 2020
B Synbiotics, prebiotics and probiotics for people with chronic kidney disease
Systematic Review The Cochrane database of systematic reviews 2023
B Effects of Prebiotics and Probiotics on Symptoms of Depression and Anxiety in Clinically Diagnosed Samples: Systematic Review and Meta-analysis of Randomized Controlled Trials
Meta Analysis Nutrition reviews 2025
View all evidence for Prebiotics →

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