Creatine Monohydrate by Ryse — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
100% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

5 Gram(s) Serving Size

60 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Creatine Monohydrate

5 Gram(s)

📊 Market median: 5.0mg (298 products) 📚 701 studies (Tier A: 5, B: 123)

This product: 5mg

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (98% of products) Structure/Function (93% of products) Nutrient (20% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Directions for use: Take 1 serving daily mixed with your favorite pre-or-post workout beverage.

⚠️ Warnings & Precautions

Warning: Ryse Up Creatine Monohydrate is intended only for healthy adults above the age of 18. Keep out of reach of children.

All individuals should consult a licensed healthcare practitioner before using this product. Do not use this product if you have been diagnosed with or have a family history of serious illness or hypo/hypertension. Discontinue use and contact a medical doctor immediately if you experience an adverse reaction.

Do not use this product if you are pregnant or nursing or planning on becoming pregnant.

🧪 Formulation Notes

1 Size 2 Strength 3 Endurance Advanced benefits of Ryse Up Creatine

Guaranteed purity

Additional Information

Facebook Twitter Instagram @ryse_supps

[Element Series]

Made in the USA with components of domestic and international origin

Product Details

UPC / SKU 8 54050 00848 2

DSLD Entry Date 2025-09-25

Product Type Non-Nutrient/Non-Botanical

Form Powder

Brand Ryse

DSLD ID 338468

Data Updated 2026-04-11

Research Evidence

739 Research Sources

47 Avg Quality Score

472 Clinical Trial

139 Meta Analysis

74 Systematic Review

47 Rct

2 Regulatory Source

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data

Meta Analysis JAMA psychiatry 2021

PubMed DOI

A HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI

A Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI Cochrane

B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis

Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024

PubMed DOI

B Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

Systematic Review BMC medicine 2019

PubMed DOI

B Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis

Meta Analysis Nutrients 2021

PubMed DOI

B The Effects of Creatine Supplementation on Upper- and Lower-Body Strength and Power: A Systematic Review and Meta-Analysis

Meta Analysis Nutrients 2025

PubMed DOI

B Meta-analysis of the efficacy and safety of Finerenone in diabetic kidney disease

Meta Analysis Medicine 2026

PubMed DOI

B Creatine and creatine analogues in hypertension and cardiovascular disease

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI

B HMG CoA reductase inhibitors (statins) for dialysis patients