Synastat

product on market Capsule Sylvan Therapeutics Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Red yeast rice contains monacolin K, which is supported by strong evidence for reducing LDL cholesterol levels. However, overall evidence coverage for this specific formulation is limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Synastat
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1200 mg
Market median: 1000.0mg (223 products) 11 studies (A:0, B:5)

Other Ingredients

Brown Rice Soy Hypromellose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions for Use: Take 2 capsules 2 times per day (morning and evening) with water at mealtimes.

Warnings & Precautions

Do not take more than 4 capsules in a 24-hour period. Immediately discontinue use if you experience any unexplained muscle pain or tenderness, especially if accompanied by flu-like symptoms.

Keep out of reach of children.

As with any dietary supplement, consult a physician if you are taking any prescription medication. Warning: Do not use if you are pregnant, can become pregnant, or are nursing; have undergone an organ transplant or major surgery within the past 6 weeks; are under 20 years of age; have active liver disease or history of liver disease; consume more than 2 drinks of alcohol per day; are allergic to soy or rice products. Should not be taken in combination with grapefruit products or prescription cholesterol-lowering drugs.

Warning: Cancer and Reproductive Harm www.P65Warnings.ca.gov

Do not use if tamper seal is broken or missing.

Warning: Do not use if you are pregnant, can become pregnant, or are nursing; have undergone an organ transplant or major surgery within the past 6 weeks; are under 20 years of age; have active liver disease or history of liver disease; consume more than 2 drinks of alcohol per day; are allergic to soy or rice products.

Formulation Notes

Sylvan Therapeutics Synastat is produced by Sylvan Bio, Inc. the only U.S. producer of red yeast rice. This product is grown, produced and bottled in the United States. Every batch is rigorously tested for consistency and quality. Synastat is designed to be used by adults to help maintain healthy cholesterol levels, in combination with a healthy lifestyle.

Red yeast rice

Helps maintain healthy LDL cholesterol levels

100% Vegetarian - Non-GMO

100% Vegetarian - Non-GMO Contains no artificial colors or flavors, corn, lactose, sugar or preservatives.

Grown & Manufactured in the USA

Sylvan Bio

Additional Information

Igen Informed Non-GMO Choice www.igenprogram.com

Metadata

Product Details

UPC / SKU8 13892 00300 0
DSLD Entry Date2025-08-22
Product TypeBotanical
FormCapsule
DSLD ID336305
Data Updated2026-04-11
Research

Research Evidence

13
Research Sources
53
Avg Quality
5
Rct
5
Meta Analysis
2
Clinical Trial
1
Regulatory Source
B Impact of red yeast rice supplementation on lipid profile: a systematic review and meta-analysis of randomized-controlled trials
Meta Analysis Expert review of clinical pharmacology 2023 PubMed DOI
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023 PubMed DOI
B Original Research: The Effects of Red Yeast Rice Supplementation on Cholesterol Levels in Adults
Meta Analysis The American journal of nursing 2017 PubMed DOI
B Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia
Rct Nutrients 2022 PubMed DOI
B Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial
Rct Asia Pacific journal of clinical nutrition 2021 PubMed DOI
C Impact of Monacolin K-Containing Supplements on Lipid Profile: A Meta-Analysis of Randomised Controlled Trials
Meta Analysis Endocrinology, diabetes & metabolism 2026 PubMed DOI
C Traditional Chinese lipid-lowering agent red yeast rice results in significant LDL reduction but safety is uncertain - a systematic review and meta-analysis
Meta Analysis Atherosclerosis 2015 PubMed DOI
C Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials
Meta Analysis Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2016 PubMed DOI
C Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: A double blind, placebo controlled randomized trial
Rct BMC complementary and alternative medicine 2015 PubMed DOI
C No additional cholesterol-lowering effect observed in the combined treatment of red yeast rice and Lactobacillus casei in hyperlipidemic patients: A double-blind randomized controlled clinical trial
Rct Chinese journal of integrative medicine 2017 PubMed DOI
View all evidence for Red Yeast Rice →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.