🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Capsule(s) Serving Size
60 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

300 mg
📊 250.0× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 300mg

Other Ingredients

Microcrystalline Cellulose Hypromellose Water Ascorbyl Palmitate Silica Medium Chain Triglyceride Oil

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take 2 capsules twice daily, or use as directed by your healthcare professional.

⚠️ Warnings & Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

🧪 Formulation Notes

Benfotiame is a well-absorbed, bioactive derivative of thiamin. Once absorbed, benfotiamine readily converts to thiamine, an essential vitamin and cofactor in many metabolic reactions, including for transketolase enzyme activity, which is critical in managing advanced glycation end products (AGE), a biomarker associated with aging. This formula is an excellent choice for improving thiamine levels and is indicated for cardiovascular and neurologic support.

Formulated to exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Vegetarian caps

Lipid-Soluble, Highly Bioavailable Thiamin Derivative

Additional Information

Storage: Keep closed in a cool, dry place out of reach of children.

GMP compliant third-party verified

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Product Details

UPC / SKU 8 71149 00361 6
DSLD Entry Date 2025-09-25
Product Type Vitamin
Form Capsule
Brand XYMOGEN
DSLD ID 335430
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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