Home/ Supplements/ Thiamine/ Benfotiamine

Benfotiamine

product on market Capsule XYMOGEN Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Benfotiamine is a fat-soluble derivative of thiamine that research suggests may help manage glycemic complications by activating transketolase. Evidence for its efficacy in supporting nerve health and glucose metabolism is moderate. The ingredient profile maintains a high safety score with no significant concerns noted.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Benfotiamine
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

300 mg
250.0× RDA — above typical dose 76 studies (A:0, B:33)

Other Ingredients

Microcrystalline Cellulose Hypromellose Water Ascorbyl Palmitate Silica Medium Chain Triglyceride Oil
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 2 capsules twice daily, or use as directed by your healthcare professional.

Warnings & Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation Notes

Benfotiame is a well-absorbed, bioactive derivative of thiamin. Once absorbed, benfotiamine readily converts to thiamine, an essential vitamin and cofactor in many metabolic reactions, including for transketolase enzyme activity, which is critical in managing advanced glycation end products (AGE), a biomarker associated with aging. This formula is an excellent choice for improving thiamine levels and is indicated for cardiovascular and neurologic support.

Formulated to exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Vegetarian caps

Lipid-Soluble, Highly Bioavailable Thiamin Derivative

Additional Information

Storage: Keep closed in a cool, dry place out of reach of children.

GMP compliant third-party verified

Scan to learn

Metadata

Product Details

UPC / SKU8 71149 00361 6
DSLD Entry Date2025-09-25
Product TypeVitamin
FormCapsule
BrandXYMOGEN
DSLD ID335430
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
Compare

Similar Products

Bio-Cetin Forte
Douglas Laboratories · Capsule
100
Benfotiamine-V 150 mg
Benfotiamine.Net · Capsule
100
Vitamin B1 250 mg
The Vitamin Shoppe · Capsule
100
Vitamin B1 250 mg
The Vitamin Shoppe · Capsule
100
Vitamin B1 (Thiamin) 100 mg
Solgar · Capsule
100
View all Thiamine products →
Thiamine research Best Thiamine All Thiamine products More from XYMOGEN View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.