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5-HTP Plus+ 200 mg

product on market Capsule NatureWise Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-5-Hydroxytryptophan is used to support serotonin production, while Vitamin B6 acts as a cofactor in the synthesis of neurotransmitters. There is moderate evidence supporting the use of 5-HTP for mood and sleep regulation. Overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP Plus+ 200 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (290% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Hypromellose Gellan Gum Rice Flour Rice Bran Extract
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults take 1 capsule daily with food or as recommended by your healthcare provider. NatureWise 5-HTP Plus+ should always be taken in conjunction with a healthy diet and regular exercise program.

Warnings & Precautions

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

NatureWise 5-HTP Plus+ should always be taken in conjunction with a healthy diet and regular exercise program.

Formulation Notes

Vegan

Plant based Non stimulating

Non-GMO

Mood, stress & sleep support

5-HTP is a plant-based mood support supplement that promotes the production of serotonin in the brain to help reduce stress, curb cravings, and encourage healthy sleep patterns. Our 5-HTP Plus+ formula includes vitamin B6 to assist with the conversion of 5-HTP into serotonin.

Promotes well-being and sleep Supports appetite control

Vitamin B6 for serotonin conversion

This product does not contain: wheat, gluten, dairy, corn, soy, eggs, tree nuts, peanuts, fish, or shellfish.

Additional Information

To learn more about NatureWise 5-HTP Plus+ and our other great products, please visit us at naturewise.com.

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU8 58081 00652 3
DSLD Entry Date2025-07-24
Product TypeOther Combinations
FormCapsule
DSLD ID332802
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.