🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Label Data

1 Vegetarian Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

5 mg (290% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 5mg UL 100mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 200mg

Other Ingredients

Hypromellose Gellan Gum Rice Flour Rice Bran Extract

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Adults take 1 capsule daily with food or as recommended by your healthcare provider. NatureWise 5-HTP Plus+ should always be taken in conjunction with a healthy diet and regular exercise program.

⚠️ Warnings & Precautions

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

NatureWise 5-HTP Plus+ should always be taken in conjunction with a healthy diet and regular exercise program.

🧪 Formulation Notes

Vegan

Plant based Non stimulating

Non-GMO

Mood, stress & sleep support

5-HTP is a plant-based mood support supplement that promotes the production of serotonin in the brain to help reduce stress, curb cravings, and encourage healthy sleep patterns. Our 5-HTP Plus+ formula includes vitamin B6 to assist with the conversion of 5-HTP into serotonin.

Promotes well-being and sleep Supports appetite control

Vitamin B6 for serotonin conversion

This product does not contain: wheat, gluten, dairy, corn, soy, eggs, tree nuts, peanuts, fish, or shellfish.

Additional Information

To learn more about NatureWise 5-HTP Plus+ and our other great products, please visit us at naturewise.com.

Store in a cool, dry place.

Product Details

UPC / SKU 8 58081 00652 3
DSLD Entry Date 2025-07-24
Product Type Other Combinations
Form Capsule
Brand NatureWise
DSLD ID 332802
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

Compare Similar Products

View all 5 Htp products →