Home/ Supplements/ Melatonin/ Melatonin 5 mg Time Release

Melatonin 5 mg Time Release

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Melatonin is supported by strong evidence for reducing sleep onset latency, while Vitamin B6 acts as a cofactor in the body's natural production of sleep-regulating hormones. Together, these ingredients target sleep cycle regulation and support neurological function. Current research indicates a high safety profile for these components when used as directed.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Melatonin 5 mg Time Release
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
100
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
5 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)

Other Ingredients

Microcrystalline Cellulose Dicalcium Phosphate Hypromellose Magnesium Stearate Stearic Acid Silicon Dioxide Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults, take 1 tablet 30 minutes before bedtime.

Warnings & Precautions

Warning: Not intended for individuals under the age of 18 years.

This product is not intended to treat insomnia or other sleep disorder.

Consult a physician before using this product if taking medication, have any medical condition, are pregnant or lactating, have an autoimmune condition or depressive disorder, using any tranquilizers or sedatives.

Melatonin may cause drowsiness or sleepiness, do not take when driving or operating heavy machinery, or consuming alcohol. If adverse reactions occur, discontinue use. For occasional short-term use only. Use only as directed and do not exceed suggested dose. This product should never substitute healthy sleep practices.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

Quick dissolving outer layer to help you fall asleep fast Controlled release inner layer to help you sleep through the night This product is helpful for occasional sleeplessness

100% drug free

Fall asleep faster, stay asleep longer Sleep support through the night

No: milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, sesame

Additional Information

Store in a cool, dry place.

Sleep

Metadata

Product Details

UPC / SKU0 47469 04837 2
DSLD Entry Date2025-06-25
Product TypeOther Combinations
FormTablet or Pill
BrandNatrol
DSLD ID332293
Data Updated2026-04-11
Research

Research Evidence

291
Research Sources
55
Avg Quality
129
Meta Analysis
93
Systematic Review
51
Rct
11
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022 PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022 PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023 PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Melatonin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.