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Melatonin + 5-HTP Advanced Time Release

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 75% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Melatonin and 5-HTP are supported by moderate evidence for improving sleep onset and quality. Vitamin B6 acts as a cofactor in the synthesis of neurotransmitters, while calcium supports overall neuromuscular function. Research coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Melatonin + 5-HTP Advanced Time Release
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Calcium
97 mg (7% DV)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
6 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)

Other Ingredients

Microcrystalline Cellulose Hypromellose Silicon Dioxide Stearic Acid Maltodextrin Beet Root Extract Cellulose Gum Magnesium Stearate Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults take 1 tablet 30 minutes before bedtime.

Warnings & Precautions

Warning: Not intended for individuals under the age of 18 years.

This product is not intended to treat insomnia or other sleep disorder.

Consult a physician before using this product if taking medication, including drugs for depression, migraine, Parkinsons disease or psychiatric disorder, or if you are using any tranquilizers or sedatives, have any medical condition, are pregnant or lactating, have an autoimmune condition or depressive disorder.

Melatonin may cause drowsiness or sleepiness, do not take when driving or operating heavy machinery, or consuming alcohol. Do not use with other supplements containing L-Tryptophan or 5-HTP. If adverse reactions occur, discontinue use. For occasional short-term use only. Use only as directed and do not exceed suggested use. This product should never substitute healthy sleep practices.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

This product is helpful for occasional sleeplessness.

Sleep Triple action formula: Relax, fall asleep faster and stay asleep longer

100% Drug free

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, sesame.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 47469 07229 2
DSLD Entry Date2025-06-25
Product TypeOther Combinations
FormTablet or Pill
BrandNatrol
DSLD ID332279
Data Updated2026-04-11
Research

Research Evidence

291
Research Sources
55
Avg Quality
129
Meta Analysis
93
Systematic Review
51
Rct
11
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022 PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022 PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023 PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.