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5-HTP Capsules 400mg

product on market Capsule BulkSupplements.com Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-Hydroxytryptophan serves as a precursor to serotonin and is used to support mood regulation. There is moderate evidence suggesting its efficacy in managing depressive symptoms. Research indicates a high safety profile when used as directed.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP Capsules 400mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
180
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Bovine Gelatin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, take 2 capsules once daily, or as directed by a physician.

Warnings & Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation Notes

5-HTP Capsules 5-Hydroxytryptophan 400 mg per serving

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Additional Information

Store in a dry, cool place

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Metadata

Product Details

UPC / SKUX003WD38HP
DSLD Entry Date2025-05-21
Product TypeAmino acid/Protein
FormCapsule
BrandBulkSupplements.com
DSLD ID329640
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.