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5-HTP 100 mg

product on market Capsule NatureWise Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

L-5-HTP is a precursor to serotonin, with moderate evidence supporting its use for mood regulation and sleep. Vitamin B6 acts as a necessary cofactor for the synthesis of neurotransmitters. Overall, the clinical evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
120
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (294% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Cellulose Rice Flour Rice Bran Extract
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults take 1 capsule twice daily with food, or as recommended by your healthcare provider. NatureWise 5-HTP should always be taken in conjunction with a healthy diet and regular exercise program.

Warnings & Precautions

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

Vegetarian

Plant based Non stimulating

Non-GMO

Mood, stress & sleep support

5-HTP is a plant-based mood support supplement that promotes the production of serotonin in the brain to help reduce stress, curb cravings, and encourage healthy sleep patterns. Our 5-HTP formula includes vitamin B6 to assist with the conversion of 5-HTP into serotonin.

Promotes well-being and sleep Supports appetite control

Vitamin B6 for serotonin conversion

This product does not contain: wheat, gluten, dairy, corn, soy, eggs, tree nuts, peanuts, fish, or shellfish.

Additional Information

To learn more about NatureWise 5-HTP and our other great products, please visit us at naturewise.com.

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU8 58081 00609 7
DSLD Entry Date2025-03-25
Product TypeOther Combinations
FormCapsule
DSLD ID327741
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.