🟢 80/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label Data

1 Veg Capsule(s) Serving Size
90 Servings
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (3125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg
135 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 135mg

Other Ingredients

Hypromellose Stearic Acid Rice Flour Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1 capsule daily as needed, preferably with a meal, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Cautions/Interactions: The tolerable upper intake level for all forms of niacin for adults is 35 mg/day based on flushing as the critical adverse effect; however, the form of niacin in this product is unlikely to cause a flushing response. High-dose niacin has been associated with liver dysfunction. Although this occurs most commonly with slow-release niacin, it can occur with any type of niacin when taken at a daily dose of > 500 mg (usually greater than equal to 3 g). Regular blood tests to evaluate liver function are recommended when using high-dose niacin. The anti-TB drug Isoniazid may increase the need for niacin. If you have liver disease, ulcers, gout, gallbladder disease, or drink alcohol. do not take high-dose niacin unless directed by your healthcare practitioner. If you are taking tetracycline, take at least two hours before or after taking niacin.

High-dose niacin may interact with statin drugs and may interfere with the absorption of tetracycline

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

How it works: Niacin is a water soluble B vitamin whose main role is to serve as a precursor for two essential biochemical coenzymes, NAD and NADP. These two cofactors participate in virtually every aspect of energy production and other metabolic processes. Niacin coenzymes help the cell use carbohydrates, fats, and proteins to produce energy and are critical for DNA replication and repair. Inositol hexanicotinate is a stable, non-flushing source of niacin. This superior source of niacin works to reduce the common "niacin-flush" associated with high dose niacin supplements.

Flush-Free Niacin Hexanicotinate form

Non-GMO

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Inositol hexanicotinate is a stable, non-flushing source of niacin. This superior source of niacin works to reduce the common "niacin-flush" problems associated with high doses of niacin supplements.

Natural color variation may occur in this product.

Product Details

UPC / SKU 7 07359 10498 3
DSLD Entry Date 2025-05-21
Product Type Other Combinations
Form Capsule
DSLD ID 326437
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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