Home/ Supplements/ Niacin/ Flush-Free Niacin 500 mg

Flush-Free Niacin 500 mg

product on market Capsule Protocol For Life Balance Safety: 80/100
80/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is supported by strong evidence for managing lipid levels, while inositol is often used to reduce the flushing response associated with niacin. Research indicates these ingredients may support metabolic health, though the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Flush-Free Niacin 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Veg Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (3125% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)
135 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Hypromellose Stearic Acid Rice Flour Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Take 1 capsule daily as needed, preferably with a meal, or as directed by your healthcare practitioner.

Warnings & Precautions

Cautions/Interactions: The tolerable upper intake level for all forms of niacin for adults is 35 mg/day based on flushing as the critical adverse effect; however, the form of niacin in this product is unlikely to cause a flushing response. High-dose niacin has been associated with liver dysfunction. Although this occurs most commonly with slow-release niacin, it can occur with any type of niacin when taken at a daily dose of > 500 mg (usually greater than equal to 3 g). Regular blood tests to evaluate liver function are recommended when using high-dose niacin. The anti-TB drug Isoniazid may increase the need for niacin. If you have liver disease, ulcers, gout, gallbladder disease, or drink alcohol. do not take high-dose niacin unless directed by your healthcare practitioner. If you are taking tetracycline, take at least two hours before or after taking niacin.

High-dose niacin may interact with statin drugs and may interfere with the absorption of tetracycline

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

How it works: Niacin is a water soluble B vitamin whose main role is to serve as a precursor for two essential biochemical coenzymes, NAD and NADP. These two cofactors participate in virtually every aspect of energy production and other metabolic processes. Niacin coenzymes help the cell use carbohydrates, fats, and proteins to produce energy and are critical for DNA replication and repair. Inositol hexanicotinate is a stable, non-flushing source of niacin. This superior source of niacin works to reduce the common "niacin-flush" associated with high dose niacin supplements.

Flush-Free Niacin Hexanicotinate form

Non-GMO

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Inositol hexanicotinate is a stable, non-flushing source of niacin. This superior source of niacin works to reduce the common "niacin-flush" problems associated with high doses of niacin supplements.

Natural color variation may occur in this product.

Metadata

Product Details

UPC / SKU7 07359 10498 3
DSLD Entry Date2025-05-21
Product TypeOther Combinations
FormCapsule
DSLD ID326437
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.