🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Veg Capsule(s) Serving Size
90 Servings
Amino acid/Protein Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg

Other Ingredients

Rice Flour Hypromellose

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested usage: Take 1 capsule 1 to 3 times daily, preferably on an empty stomach before bedtime, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Cautions/interactions: May cause mild, but transient GI discomfort. Individuals with a history of cardiac conditions, use only under the direction of your healthcare practitioner.

5-HTP should be used with caution in combination with any serotonergic drug or herb, including SSRIs, MAOIs and St. John's wort. If you are taking any of these medications or if you are planning any surgical procedures, consult your healthcare practitioner prior to using this product.

Not recommended for pregnant or nursing women.

Not manufactured with wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nuts ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

How it works: 5-HTP is the intermediate precursor in the natural synthesis of serotonin, a neurotransmitter that helps to regulate mood, appetite, and sleep/wake cycles. 5-HTP readily crosses the blood-brain barrier and clinical studies suggest that 5-HTP can support healthy serotonin levels. Serotonin is associated with a positive mood and provides a substrate for the production of melatonin. 5-HTP is extracted from the bean of the African plant Griffonia simplicifolia, a natural vegetable source.

Natural source Supports a positive mood

Non-GMO

Vegetarian/vegan

Not manufactured with wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nuts ingredients.

Natural color variation may occur in this product.

(5-Hydroxytryptophan)

Product Details

UPC / SKU 7 07359 10105 0
DSLD Entry Date 2025-02-23
Product Type Amino acid/Protein
Form Capsule
DSLD ID 326417
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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