E 180 mg (400 IU) by 21st Century — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Softgel(s) Serving Size

250 Servings

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin E

180 mg (1200% DV)

📊 12.0× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 180mg UL 1000mg

Other Ingredients

Gelatin Glycerin Soybean Oil Water, Purified

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (98% of products) Structure/Function (81% of products) Nutrient (56% of products) Qualified Health (2% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a vitamin supplement, adults take one (1) softgel with any meal, twice daily or as directed by a healthcare provider.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains: soy.

🧪 Formulation Notes

Vitamin E is an antioxidant nutrient and supports the immune system.

No added sugar, salt, yeast, preservatives, artificial flavors or colors.

Antioxidant support

Gluten Free

Guaranteed Quality Laboratory Tested Trusted Quality for over 30 years

Additional Information

Individual results may vary.

Store in a cool, dry place.

Product Details

UPC / SKU 7 40985 22730 5

DSLD Entry Date 2025-03-25

Product Type Vitamin

Form Softgel Capsule

Brand 21st Century

DSLD ID 326325

Data Updated 2026-04-11

Research Evidence

253 Research Sources

55 Avg Quality Score

128 Meta Analysis

52 Systematic Review

41 Rct

24 Clinical Trial

3 Regulatory Source

1 Narrative Review

1 Other

1 Guideline

1 Openfda Safety

A Vitamin E supplementation in pregnancy

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Systematic Review The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin E for Alzheimer's disease and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2008

PubMed DOI Cochrane

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

A Exercise for intermittent claudication

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2021

PubMed DOI

A Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis

Meta Analysis European journal of clinical nutrition 2023

PubMed DOI

A Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Rct JAMA 2011

PubMed DOI

A Vitamin E for Alzheimer's dementia and mild cognitive impairment

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

B Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.

Guideline JAMA 2022

PubMed DOI

View all evidence for Vitamin E →