Berberine by Simply Natures Pure — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
67% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size

120 Servings

Other Combinations Product Type

67% Evidence Coverage

Supplement Facts — Evidence Check

Chromium

100 mcg (80% DV)

✅ 2.9× RDA — within safe limits 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.1mg

Berberine Hydrochloride

500 mg

📊 Market median: 500.0mg (234 products) 📚 95 studies (Tier A: 0, B: 35)

This product: 500mg

Cinnamon

100 mg

Other Ingredients

Vegetable Capsule

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (86% of products) Nutrient (4% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement, adults take one (1) capsule once or twice daily with a meal, or as directed by a healthcare professional.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose. Do not use if safety seal is damaged or missing.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or taking prescription medication should consult a physician before taking this or any dietary supplement.

🧪 Formulation Notes

Supports cardiovascular health Supports gastrointestinal health Immune function support Weight management aid

Additional Information

Store in a cool, dry place.

Made in the USA GMP Good Manufacturing Practice Consistent Quality

Please Recycle

Product Details

UPC / SKU X001E5U231

DSLD Entry Date 2025-01-23

Product Type Other Combinations

Form Capsule

Brand Simply Natures Pure

DSLD ID 323393

Data Updated 2026-04-11

Research Evidence

98 Research Sources

55 Avg Quality Score

48 Systematic Review

39 Meta Analysis

4 Rct

4 Clinical Trial

1 Other

1 Narrative Review

1 Openfda Safety

B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018

PubMed DOI

B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2022

PubMed DOI

B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023

PubMed DOI

B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2019

PubMed DOI

B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis The Journal of nutrition 2023

PubMed DOI

B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Meta Analysis Journal of translational medicine 2024

PubMed DOI

B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature

Systematic Review International journal of molecular sciences 2024

PubMed DOI

B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Meta Analysis The American journal of Chinese medicine 2019

PubMed DOI

B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies

Meta Analysis International journal of molecular sciences 2023

PubMed DOI

B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial

Rct JAMA network open 2025

PubMed DOI

View all evidence for Berberine →