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Berberine

product on market Capsule Simply Natures Pure Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Berberine hydrochloride and cinnamon are supported by moderate evidence for assisting in blood glucose management. Chromium is frequently used to improve insulin sensitivity, though research results vary. Together, these ingredients target metabolic health through established biochemical pathways.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Berberine
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mcg (80% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)
Cinnamon
100 mg

Other Ingredients

Vegetable Capsule
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, adults take one (1) capsule once or twice daily with a meal, or as directed by a healthcare professional.

Warnings & Precautions

Caution: Do not exceed recommended dose. Do not use if safety seal is damaged or missing.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or taking prescription medication should consult a physician before taking this or any dietary supplement.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or taking prescription medication should consult a physician before taking this or any dietary supplement. Keep out of reach of children.

Formulation Notes

Supports cardiovascular health Supports gastrointestinal health Immune function support Weight management aid

Additional Information

Store in a cool, dry place.

Made in the USA GMP Good Manufacturing Practice Consistent Quality

Please Recycle

Metadata

Product Details

UPC / SKUX001E5U231
DSLD Entry Date2025-01-23
Product TypeOther Combinations
FormCapsule
BrandSimply Natures Pure
DSLD ID323393
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.