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Berberine 500

product on market Capsule AvalonX Powered by MDLogic Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Berberine has demonstrated moderate to strong evidence in supporting healthy blood glucose levels and metabolic function. Research indicates it may help improve insulin sensitivity and lipid profiles. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Berberine 500
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1000 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)

Other Ingredients

Hypromellose Hydroxypropylmethylcellulose Monolaurin Microcrystalline Cellulose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommended use: As a dietary supplement, take 1-2 capsules, one to two times per day, or as recommended by a healthcare professional.

Warnings & Precautions

Warning: Consult with a health care professional before use and/or if you are pregnant, lactating, or undergoing treatment for a medical condition.

Do not exceed recommended dosage. Discontinue use if any adverse reactions occur and contact a health care professional. Do not use if seal under cap is broken or missing.

Keep out of reach of children.

Formulation Notes

Berberine is a powerful, natural plant alkaloid shown to help regulate blood glucose and cholesterol levels already in normal range, and modulate adipose tissue which can support metabolic health.

Gluten Free BPA free

Purity Potency Tested

Contains no milk, soy, egg, fish, peanuts, crustacean shellfish, tree nuts, wheat, gluten, rice, or yeast. No artificial colors or flavors. No toxic fillers, including stearates and palmitates.

Lab tested for contaminants, including heavy metals and mold. Unlike most enteric coatings, our capsules do not contain plastic phthalates.

Amber glass bottles eliminate leaching of toxins into our bodies and planet.

Additional Information

Store tightly closed in a cool, dry place.

Made in the USA from Global Ingredients Manufactured by a GMP Certified Company

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Metadata

Product Details

UPC / SKU8 97395 00286 2
DSLD Entry Date2025-03-25
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID320614
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.