🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
240 Servings
Non-Nutrient/Non-Botanical Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

Calcium
50 mg (4% DV)
20 mg (5% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 20mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg

Other Ingredients

Gelatin

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) No Allergies Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use Consume one capsule daily. You can increase your intake as required or as guided by your physician.

⚠️ Warnings & Precautions

Warning Not for use if you are pregnant or lactating, driving a motor vehicle, operating machinery or using sedative or antidepressant drugs. Discontinue use at least two days before any procedure requiring general anesthesia.

If you are under a physician's care, seek their advice before using this product.

🧪 Formulation Notes

Since 1979, Unsurpassed purity, quality, and efficacy.

100% Solar

5-Hydroxytryptophan Natural Griffonia Simplicifolia

5-HTP 100 provides a concentrated natural source of the amino acid, 5-hydroxytryptophan (5-HTP) from Griffonia simplicifolia seed. 5-HTP is a metabolic intermediate of the essential amino acid tryptophan and is the immediate precursor to the important neurotransmitter serotonin. As a result, 5-HTP plays an essential role in our body's synthesis of serotonin, which helps to enhance sleep quality while also promoting positive mood and supporting digestive system function and appetite control. Serotonin levels have been shown to be associated with the regulation of sleep, mood, appetite and the digestive process, which makes supplementing 5-HTP an important means of supporting these essential functions. Clinical research has shown that 5-HTP has the ability to cross the blood-brain barrier providing a direct means of promoting serotonin production and its benefits. Furthermore, 5-HTP also supports melatonin synthesis, which helps to regulate normal sleep schedule and may enhance sleep quality. 5-HTP can also promote healthy levels of other essential neurotransmitters and other neurochemicals, including dopamine and norepinephrine. In short, 5-HTP 100 is a simple, natural means of supporting the brain and healthy neurochemistry, along with sleep, mood and even digestive function.

Contains no additives or common allergens

Contains no milk, soy, yeast, corn, wheat, gluten, sodium, salt, sugar, fat, cholesterol, color, preservative, common allergens, genetically modified (GMO) ingredients or manufacturing additives.

Additional Information

For questions about the use of this product call 800.800.1200.

Questions? Reorders? 800.800.1200 procaps.com Andrew Lessman

Product Details

UPC / SKU 727821
DSLD Entry Date 2024-12-21
Product Type Non-Nutrient/Non-Botanical
Form Capsule
DSLD ID 320052
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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