🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

3 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

500 mg
📊 Market median: 2000.0mg (275 products)
Median 2000.0mg This product: 500mg
66.7 mg
📊 Market median: 500.0mg (143 products)
This product: 66.7mg
L-Glutathione
66.7 mg
BioPerine
1.7 mg

Other Ingredients

Hypromellose L-Leucine

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (91% of products) Nutrient (29% of products) No Claim (2% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Recommended use: A source of substrates for nitric oxide production, a vasodilator. Directions: Adult(s) (18 years and over) 3 capsules, 2 times per day. Ensure to drink optimal fluid before, during and after exercise. Duration of use: Consult a healthcare practitioner for use beyond 2 weeks.

⚠️ Warnings & Precautions

Warnings: Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or if you suffer from cardiovascular disease and are attempting an increase in physical activity or if your cardiovascular condition worsens. Consult a health care practitioner prior to use if you are taking any other medications or natural health products, as black pepper/piperine may alter their effectiveness , or if you are taking medication for cardiovascular diseases, erectile dysfunction, and/or blood thinners.

Duration of use: Consult a healthcare practitioner for use beyond 2 weeks. Contra-indications: Do not use if you have had a heart attack/myocardial infraction. Known adverse reactions: some people may experience gastrointestinal discomfort/disturbances. Do not use if seal is broken. Security feature is self evident

Allergen warning: This product is manufactured in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and shellfish.

🧪 Formulation Notes

1500 mg L-citrulline 500 mg Nitrosigine 200 mg Glutathione Per serving

Supports production of nitric oxide

Additional Information

NPN 80125263

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Product Details

UPC / SKU 6 72691 00452 2
DSLD Entry Date 2024-10-24
Product Type Other Combinations
Form Capsule
DSLD ID 319463
Data Updated 2026-04-11

Research Evidence

12 Research Sources
45 Avg Quality Score
6 Rct
5 Clinical Trial
1 Meta Analysis
C Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis Journal of the International Society of Sports Nutrition 2021
C Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
Rct Nutrients
C Effects of Acute Citrulline Malate Supplementation on CrossFit® Exercise Performance: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study.
Rct Nutrients
C Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.
Rct Nutrients
C Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity
Clinical Trial ClinicalTrials.gov 2021
C Effects of L-Citrulline or Citrulline-malate on Neuromuscular Performance in Resistance-trained Adults
Clinical Trial ClinicalTrials.gov 2022
C Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults.
Rct Journal of the International Society of Sports Nutrition
C Effects of Combined Versus Single Supplementation of Creatine, Beta-Alanine, and L-Citrulline During Short Sprint Interval Training on Basketball Players' Performance: A Double-Blind Randomized Placebo-Controlled Trial.
Rct International journal of sports physiology and performance
C Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance.
Rct Scientific reports
C L-Citrulline in Peripheral Artery Disease
Clinical Trial ClinicalTrials.gov 2016
View all evidence for Citrulline →

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