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Berberine HCL 500 mg

product on market Capsule Good State Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Berberine hydrochloride is supported by moderate to strong evidence for helping manage blood glucose levels and lipid profiles. Research indicates it may improve insulin sensitivity by activating AMPK. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Berberine HCL 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (234 products) 95 studies (A:0, B:35)

Other Ingredients

Rice Flour Cellulose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Adults: Take 1 capsule with 6 - 8 oz of water or juice 15 minutes before meals. Children: Please consult a physician. Use more if needed or as recommended by your healthcare professional. New users should gradually increase dosing. Do not exceed 3 capsules per day. Do not take on an empty stomach. Do not take without water or juice. Results will vary.

Warnings & Precautions

Warning: Do not use if you are pregnant attempting to become pregnant, or nursing. Consult a healthcare professional before using this, or any other dietary supplement, especially if you have, or suspect you may have, any medical condition, or if you are taking anticogulants, blood thinners, or any other dietary supplement, prescription, or over-the-counter medications, as combining these products may cause side effects.

Discontinue use and immediately call a healthcare professional if you experience any adverse reactions. Do not exceed recommended serving.

Note: No product claims are being made or implied. Research is ongoing.

Children: Please consult a physician. Caution: Keep out of reach of children.

Do not exceed 3 capsules per day. Do not take on an empty stomach. Do not take without water or juice. Always speak with your physician before using any dietary supplement. Do not use if tamper evident seal is broken or missing.

Formulation Notes

This product is made with high quality Berberine HCL and not Berberine Sulfate.

This product is made with high quality Berberine HCL and not Berberine Sulfate.

Formulated for cholesterol support High bioavailability Professional Grade

Contains 500 mg Berberine HCL Good State's Nano Ionic Supplements

Good State is proud to follow Good Manufacturing Practices (GMP) 100% satisfaction guaranteed

Additional Information

For increased support, try Glyco-X 500

Made in USA

For freshness after opening, store in a cool, dark place.

FBA USA Text support +1-215-608-1124 Give your body what it needs! Health Solutions

Metadata

Product Details

UPC / SKU8 50023 84745 4
DSLD Entry Date2024-07-25
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
DSLD ID310819
Data Updated2026-04-11
Research

Research Evidence

98
Research Sources
55
Avg Quality
48
Systematic Review
39
Meta Analysis
4
Rct
4
Clinical Trial
1
Other
1
Narrative Review
1
Openfda Safety
B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 PubMed DOI
B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2019 PubMed DOI
B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis The Journal of nutrition 2023 PubMed DOI
B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
Meta Analysis Journal of translational medicine 2024 PubMed DOI
B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature
Systematic Review International journal of molecular sciences 2024 PubMed DOI
B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Meta Analysis The American journal of Chinese medicine 2019 PubMed DOI
B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
Rct JAMA network open 2025 PubMed DOI
View all evidence for Berberine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.