Home/ Supplements/ Melatonin/ Melatonin + 5-HTP Time Release

Melatonin + 5-HTP Time Release

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Melatonin and 5-HTP are supported by moderate to strong evidence for promoting sleep and mood regulation. Vitamin B6 serves as a cofactor in the synthesis of these neurotransmitters. Research indicates these ingredients are generally well-tolerated when used as directed.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Melatonin + 5-HTP Time Release
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (590% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
50 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
6 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Methylcellulose Silicon Dioxide Stearic Acid Hypromellose Maltodextrin Cellulose Gum Beet Root Extract Magnesium Stearate Glycerin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 tablet 20 minutes before bedtime.

Warnings & Precautions

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition or are taking prescription drugs including drugs for depression, migraine, Parkinson's disease or psychiatric disorder, or if you are using any tranquilizers or sedatives. Do not use if you are pregnant or lactating, or under the age of 18 years. Do not use with other supplements containing L-Tryptophan or 5-HTP.

Do not use if you are pregnant or lactating, or under the age of 18 years.

Consult your healthcare professional if you have an autoimmune condition or depressive disorder. Do not take when operating machinery or driving a vehicle.

Keep out of reach of children.

Formulation Notes

Ingredients for a Great Night's Sleep 5-HTP - A naturally occurring amino acid that increases production of Serotonin to promote calm and relaxation and help with occasional anxiety Melatonin - A naturally occurring hormone produced by the brain to help the body manage the "Sleep-Wake" cycle Vitamin B-6 - Essential vitamin that supports the body's natural production of Melatonin

Melatonin and 5-HTP are 100% drug-free and non-habit forming.

Melatonin and 5-HTP are 100% drug-free and non-habit forming.

Bi-Layer Controlled Release Tablet

Ingredients are released in stages to more effectively help you relax, fall asleep and stay asleep

Advanced Sleep Triple Action Formula Calm the Mind Fall Asleep Faster Stay Asleep Longer

100% Drug-Free

Vegetarian

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, yeast, artificial colors or flavors, added sugar or preservatives

Natrol Advanced Sleep Melatonin + 5-HTP Advanced Triple Action sleep formulation to help you overcome the three most common sleep concerns - a racing mind, difficulty falling asleep and difficulty sleeping through the night - to help you get the best sleep so you can wake up refreshed. Calm the Mind 5-HTP releases quickly to help calm the racing mind so you can relax before falling asleep Fall Asleep Faster Melatonin releases quickly to help you fall asleep faster Stay Asleep Longer A controlled release of Melatonin helps you sleep through the night Melatonin is a Nightime Sleep Aid for Occasional Sleeplessness

Additional Information

Actual Size

Store in a cool, dry place.

Metadata

Product Details

DSLD Entry Date2024-02-22
Product TypeOther Combinations
FormTablet or Pill
BrandNatrol
DSLD ID306526
Data Updated2026-04-11
Research

Research Evidence

291
Research Sources
55
Avg Quality
129
Meta Analysis
93
Systematic Review
51
Rct
11
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022 PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022 PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023 PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.