Home/ Supplements/ Vitamin D/ D3 125 mcg (5000 IU)

D3 125 mcg (5000 IU)

product on market Softgel Capsule 21st Century Safety: 60/100
60/100

Review before taking

  • Vitamin D3: 0.125mg is 1.2× the Tolerable Upper Intake Level (0.1mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Vitamin D3 is supported by strong evidence for maintaining bone health and supporting immune function. However, the safety score of 60 indicates potential concerns, as high doses may lead to toxicity in some individuals. Users should be mindful of the 5000 IU potency relative to daily requirements.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Vitamin D3: 0.125mg is 1.2× the Tolerable Upper Intake Level (0.1mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a lower score because the amount of Vitamin D3 exceeds the recommended daily upper limit for safety.

Label

Product Label

Label for D3 125 mcg (5000 IU)
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
110
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

125 mcg (625% DV)
Exceeds UL by 1.2× (UL: 0.1 mg) 608 studies (A:16, B:251)

Other Ingredients

Soybean Oil Gelatin Glycerin Water, Purified Corn Oil
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Consult your healthcare provider prior to taking high dose Vitamin D supplements. Adults take one (1) softgel daily with any meal or as directed by a healthcare provider.

Warnings & Precautions

Do not exceed recommended dosage. Individual results may vary.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, taking any medications, have a medical condition (especially hypercalcemia kidney disease or hyperparathyroidism), or are planning a medical procedure.

Do not take with other supplements that contain Vitamin D, such as multivitamins. Stop use and contact a physician if adverse reactions occur. Do not use if product appears to be tampered with or seal is broken.

Keep out of reach of children.

Contains soy.

Formulation Notes

Strong bones & immune support

Gluten free Non-GMO

Guaranteed quality Laboratory tested Trusted quality for over 30 years

Vitamin D3 is essential for absorption of calcium and supports bones, teeth and the immune system.

No added sugar, yeast, preservatives, artificial flavors or colors.

Actual size

Additional Information

Store in a cool, dry place.

New

Metadata

Product Details

UPC / SKU7 40985 28059 1
DSLD Entry Date2024-01-24
Product TypeVitamin
FormSoftgel Capsule
Brand21st Century
DSLD ID304122
Data Updated2026-04-11
Research

Research Evidence

872
Research Sources
53
Avg Quality
309
Meta Analysis
309
Clinical Trial
111
Rct
71
Systematic Review
55
Guideline
4
Cochrane Review
4
Regulatory Source
2
Other
2
Narrative Review
2
Observational
1
Openfda Safety
A Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Vitamin D supplementation for prevention of cancer in adults
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Interventions for preventing falls in older people in care facilities and hospitals
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Drugs for preventing lung cancer in healthy people
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A High prevalence of vitamin D deficiency in Asia: A systematic review and meta-analysis
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Interventions for preventing falls in older people living in the community
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
View all evidence for Vitamin D →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.