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Niacin Inositol Hexanicotinate 500 mg

product on market Capsule Sundown Naturals Safety: 80/100
80/100

This product is generally safe

  • Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin and inositol are utilized to support metabolic function and cellular signaling. Research provides moderate evidence for their role in lipid management and insulin sensitivity, though the specific hexanicotinate form is often used to reduce flushing. Evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Niacin Inositol Hexanicotinate 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg (2000% DV)
Exceeds UL by 11.4× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Gelatin Stearic Acid Silica Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Do not take on an empty stomach.

DIRECTIONS: FOR ADULTS, TAKE ONE (1) CAPSULE DAILY, PREFERABLY WITH A MEAL.

Warnings & Precautions

WARNING: Not intended for use by pregnant or nursing women. If you are taking any medications, consult your doctor before use.

KEEP OUT OF REACH OF CHILDREN.

**NOTICE: Most people should not experience flushing when using this product. However, a few sensitive individuals may experience some flushing.

Discontinue use and consult your doctor if any adverse reactions occur.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

Formulation Notes

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Fish. Sodium Free.

Additional Information

{Bottle} PLEASE RECYCLE

GUARANTEED LABORATORY TESTED QUALITY

As a reminder, discuss the supplements and medications you take with your health care providers.

STORE IN A DRY PLACE AND AVOID EXCESSIVE HEAT.

Smart Facts Niacin promotes heart health, energy metabolism and nervous system health.* Niacin also helps maintain healthy functions of the digestive system and skin.* Flush-free means that you don't experience the familiar "flush" when using this supplement.**

Flush Free

Promotes Heart Health & Energy Metabolism*

U.S. LAB POTENCY TESTED

Prod. No. 44891 08F B1660 CAB

Metadata

Product Details

UPC / SKU0 30768 03787 1
DSLD Entry Date2014-02-26
Product TypeOther Combinations
FormCapsule
DSLD ID30370
Data Updated2026-04-11
Research

Research Evidence

32
Research Sources
50
Avg Quality
19
Rct
7
Meta Analysis
3
Clinical Trial
2
Other
1
Systematic Review
B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024 PubMed DOI
B Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines
Meta Analysis The Journal of clinical endocrinology and metabolism 2024 PubMed DOI
B Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes
Meta Analysis The Cochrane database of systematic reviews 2023 PubMed DOI
B Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis
Meta Analysis Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2022 PubMed DOI
B Effects of myo-inositol vs. metformin on hormonal and metabolic parameters in women with PCOS: a meta-analysis
Meta Analysis Irish journal of medical science 2023 PubMed DOI
B Inositol for subfertile women with polycystic ovary syndrome
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
B Treatment of lean PCOS teenagers: a follow-up comparison between Myo-Inositol and oral contraceptives
Rct European review for medical and pharmacological sciences 2021 PubMed DOI
B The 40:1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios
Rct European review for medical and pharmacological sciences 2019 PubMed DOI
C Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis
Meta Analysis Expert review of endocrinology & metabolism 2024 PubMed DOI
C Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-controlled clinical trial.
Rct International journal of food sciences and nutrition PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.