🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
60 Servings
Amino acid/Protein Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg

Other Ingredients

Hypromellose Microcrystalline Cellulose Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Adult use: Take 1 capsule daily, with or without food, or as recommended by your nutritionally informed physician.

⚠️ Warnings & Precautions

Warning: Not to be used when taking MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), or other anti-depressant medications. It should also not be used by individuals taking any of the category of medications known as "triptans."

Keep out of the reach of children.

May impair your ability to drive or operate machinery.

🧪 Formulation Notes

Doctor's Best 5-HTP (5-hydroxy L-tryptophan) contains a naturally occurring metabolite of the amino acid tryptophan. 5-HTP is extracted from the seeds of the Griffonia simplicifolia plant. 5-HTP is converted in the brain to serotonin, a neurotransmitter substance found at the junctions (synapses) between neurons. It produces a calming and relaxing effect providing support to help maintain mental, emotional well-being, and to promote healthy sleep.

Doctor's Best 5-HTP is tested to ensure that it does not contain "Peak X."

Helps promote healthy sleep Helps promote calm and relaxation Helps support mental and emotional well-being

Non-GMO/Gluten free/Soy free/Vegan

Non-GMO/Gluten free/Soy free/Vegan

Additional Information

Vegan

Store in a cool dry place.

Product Details

UPC / SKU 7 53950 00077 3
DSLD Entry Date 2024-02-22
Product Type Amino acid/Protein
Form Capsule
DSLD ID 302635
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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