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Defend

product on market Capsule Huge Nutrition Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 71% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains milk thistle and N-acetyl cysteine, which have moderate evidence for supporting liver health and detoxification. Saw palmetto and peppermint are included for prostate and digestive support, though evidence for these specific applications is more limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Defend
Open Full PDF View on NIH DSLD →
Details

Label Data

4 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
71%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 250.0mg (562 products) 55 studies (A:0, B:19)
Market median: 600.0mg (7 products) 39 studies (A:2, B:13)
Market median: 60.0mg (107 products) 1 studies — no high-quality reviews
Market median: 320.0mg (426 products) 26 studies (A:0, B:5)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Red Clover Flower Extract
200 mg
Market median: 333.0mg (166 products) 9 studies (A:0, B:2)

Other Ingredients

Gelatin Rice Flour Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement, take four (4) capsules with 8-12 fl oz of water.

Warnings & Precautions

Warning: For use by healthy adults only, not recommended for persons under the age of 18.

Do not use if you are pregnant or nursing.

Seek advice from a healthcare professional before taking if you have any preexisting medical condition to ensure it is safe to take this product. In case of accidental overdose, contact a poison control center immediately.

Keep out of the reach of children.

Formulation Notes

Powerful on cycle support Total organ protection Supports healthy lipids

Additional Information

Made in USA GMP Good Manufacturing Practice

Metadata

Product Details

UPC / SKU7 28614 77849 7
DSLD Entry Date2023-12-14
Product TypeOther Combinations
FormCapsule
BrandHuge Nutrition
DSLD ID299800
Data Updated2026-04-11
Research

Research Evidence

69
Research Sources
55
Avg Quality
34
Meta Analysis
26
Systematic Review
5
Rct
3
Clinical Trial
1
Openfda Safety
A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis
Meta Analysis Japan journal of nursing science : JJNS 2024 PubMed DOI
B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications
Meta Analysis Asia Pacific journal of clinical nutrition 2025 PubMed DOI
B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
B Pharmacotherapy for trichotillomania
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review
Meta Analysis Medicine 2024 PubMed DOI
B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis
Meta Analysis Medicine 2020 PubMed DOI
B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
Meta Analysis Annals of hepatology 2024 PubMed DOI
View all evidence for Milk Thistle →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.