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Melatonin 20 mg

product on market Tablet or Pill NaturesPlus Safety: 60/100
60/100

Review before taking

  • Melatonin: 20mg is 2.0× the Tolerable Upper Intake Level (10mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Melatonin is a hormone used to regulate sleep-wake cycles, with strong evidence supporting its use for short-term sleep onset. However, the 20 mg dosage is significantly higher than typical supplemental amounts. Due to the low safety score, potential concerns regarding high-dose side effects or hormonal disruption should be noted.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Melatonin: 20mg is 2.0× the Tolerable Upper Intake Level (10mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains 20mg of melatonin, which is twice the recommended tolerable upper intake level of 10mg.

Label

Product Label

Label for Melatonin 20 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
90
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

20 mg
Exceeds UL by 2.0× (UL: 10 mg) 240 studies (A:2, B:109)

Other Ingredients

Microcrystalline Cellulose Rice Bran extract Tapioca Maltodextrin Sunflower Lecithin Palm Oil Guar Gum Cellulose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one tablet about 30 minutes before bedtime.

Warnings & Precautions

Keep out of reach of children.

Warning: May cause drowsiness.

Not intended for those under 18, pregnant or nursing.

Not intended for those under 18, pregnant or nursing. Consult your physician before use if you are taking any medications or have any medical conditions, including depression, seasonal affective disorder, schizophrenia, autoimmune disease, high blood pressure, asthma or epilepsy.

Discontinue use and consult your physician if any adverse reactions occur. Do not drive, operate machinery or consume alcohol while taking this product. Do not take daily for more than two months; stop for one week between two-month supplementation period.

Formulation Notes

Fast acting Promotes healthy sleep Sleep support

Free from artificial colors and artificial preservatives. Free from all of the major allergens identified in the U.S. Food Allergen Labeling and Consumer Protection Act.

Vegan

Gluten free

Magnesium stearate free

Additional Information

Keep tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU0 97467 47628 8
DSLD Entry Date2023-10-24
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
BrandNaturesPlus
DSLD ID298559
Data Updated2026-04-11
Research

Research Evidence

291
Research Sources
55
Avg Quality
129
Meta Analysis
93
Systematic Review
51
Rct
11
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022 PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022 PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023 PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Melatonin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.