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SAM-e 400 mg

product on market Other (e.g. tea bag) Meijer Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

S-Adenosyl Methionine is used to support mood and joint health. Research provides moderate evidence for its efficacy in managing depressive symptoms and osteoarthritis. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAM-e 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Enteric Coated Caplet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Dicalcium Phosphate Cellulose Stearic Acid Croscarmellose Magnesium Stearate Silica Cellulose Triacetin Propylene Glycol Methacrylic Acid Titanium Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement for adults, take one (1) enteric coated caplet one to three times daily on an empty stomach at least 30 minutes prior to meals.

Warnings & Precautions

Caution: If you are pregnant, nursing a baby or considering becoming pregnant, ask a doctor before using this product. If you take a prescription medication or have any medical condition, consult a physician before using this product.

If any adverse reactions occur, immediately stop using this product and consult your doctor. Do not eat freshness packet. Keep packet in bottle until all product has been consumed. If seal under cap is damaged or missing, do not use.

Keep out of reach of children.

Formulation Notes

Enteric coated

General health

Supports joint health Supports mood & emotional well-being

SAM-e is a compound that is formed naturally in the body from the amino acid methionine. However, various factors, such as age and diet, can cause levels of SAM-e to fluctuate or decline.

Meijer 400 mg SAM-e caplets have an enteric coating that optimizes absorption to help support joint health and emotional well being.

Supports healthy mood and joint comfort

No wheat, soy, dairy, artificial flavors, preservatives, gluten, artificial sweetener, fish, lactose.

GF Gluten free

Additional Information

Our quality guarantee www.mejer.com/satisfaction The Meijer Family

Do not eat freshness packet. Keep packet in bottle until all product has been consumed.

Store at room temperature (59 degrees F-86 degrees F) (15 degrees C-30 degrees C).

Metadata

Product Details

DSLD Entry Date2023-08-23
Product TypeNon-Nutrient/Non-Botanical
FormOther (e.g. tea bag)
BrandMeijer
DSLD ID296595
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.