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5-HTP (5-Hydroxytryptophan) 50 mg

product on market Capsule Pure Encapsulations Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP serves as a precursor to serotonin and is researched for its role in supporting mood and sleep regulation. There is moderate evidence suggesting its effectiveness for managing depressive symptoms. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP (5-Hydroxytryptophan) 50 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
180
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Plant Fiber Cellulose Water
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendations: As a dietary supplement, take 1 capsule, 1-4 times daily, before meals, or as directed by a health professional.

Warnings & Precautions

Keep out of the reach of children.

Use only if safety seal is intact.

Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, particularly psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.

Formulation Notes

Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Supports brain serotonin levels

Gluten-free, Non-GMO & hypoallergenic

Gluten-free, Non-GMO & hypoallergenic

Additional Information

Store in a cool, dry place.

Warning: See side panel.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

GFCO.org (Gluten-Free Certification Organization)

Metadata

Product Details

UPC / SKU7 66298 00154 8
DSLD Entry Date2023-08-23
Product TypeAmino acid/Protein
FormCapsule
DSLD ID296189
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.