Silymarin 80 by Metagenics — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

90 Servings

Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Milk Thistle Seed Extract

112 mg

📊 Market median: 250.0mg (562 products) 📚 53 studies (Tier A: 0, B: 19)

This product: 112mg

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Silica Stearic Acid Magnesium Stearate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (4% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one tablet three times daily or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: If pregnant or nursing, or taking medication, consult your healthcare practitioner before use.

Keep out of the reach of children.

Practitioner exclusive

🧪 Formulation Notes

Silymarin 80 features milk thistle seed extract providing 56 mg of silymarin per serving. Milk thistle seed extract is noted for its antioxidant properties and support of healthy liver function. Liver support formula

This product is non-GMO, gluten-free, and vegetarian.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Additional Information

Storage: Keep tightly closed in a cool, dry place. Do not refrigerate.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Product Details

UPC / SKU 7 55571 02820 4

DSLD Entry Date 2023-08-23

Product Type Botanical

Form Tablet or Pill

Brand Metagenics

DSLD ID 295859

Data Updated 2026-04-11

Research Evidence

69 Research Sources

55 Avg Quality Score

34 Meta Analysis

26 Systematic Review

5 Rct

3 Clinical Trial

1 Openfda Safety

A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI Cochrane

B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis

Meta Analysis Japan journal of nursing science : JJNS 2024

PubMed DOI

B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications

Meta Analysis Asia Pacific journal of clinical nutrition 2025

PubMed DOI

B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases

Meta Analysis The Cochrane database of systematic reviews 2007

PubMed

B Pharmacotherapy for trichotillomania

Meta Analysis The Cochrane database of systematic reviews 2021

PubMed DOI

B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2022

PubMed DOI

B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review

Meta Analysis Medicine 2024

PubMed DOI

B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury

Meta Analysis BMC complementary medicine and therapies 2025

PubMed DOI

B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis

Meta Analysis Medicine 2020

PubMed DOI

B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis

Meta Analysis Annals of hepatology 2024

PubMed DOI

View all evidence for Milk Thistle →