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MSM/Glucosamine

product on market Capsule GNC Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Glucosamine and MSM are commonly used to support joint health and cartilage maintenance. Research provides moderate evidence that these ingredients may help reduce joint discomfort, though clinical results vary. The current evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for MSM/Glucosamine
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Non-Nutrient/Non-Botanical
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

MSM
500 mg
Market median: 1000.0mg (2 products)
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)

Other Ingredients

Gelatin
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one to three capsules daily.

Warnings & Precautions

Caution: If you are allergic to shellfish, please consult your health care professional before taking this product.

Keep out of reach of children

Formulation Notes

Made in the USA

MSM/Glucosamine Methylsulfonyl-methane with glucosamine MSM 500 mg Glucosamine 500 mg

Potency of MSM verified by GNC procedure #5405. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

No sugar, no starch, no artificial colors, no artificial flavors, sodium free, no wheat, no gluten, no corn, no soy, no dairy, yeast free.

Lignisul MSM

Additional Information

For more information: 1-888-462-2548

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 48107 04887 7
DSLD Entry Date2023-07-18
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandGNC
DSLD ID288677
Data Updated2026-04-11
Research

Research Evidence

39
Research Sources
50
Avg Quality
20
Rct
9
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Regulatory Source
1
Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012 PubMed DOI
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023 PubMed DOI
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006 PubMed
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023 PubMed DOI
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009 DOI
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022 PubMed DOI
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016 PubMed DOI
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018 PubMed DOI
View all evidence for Glucosamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.