🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
90 Servings
Non-Nutrient/Non-Botanical Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

MSM
500 mg
📊 Market median: 1000.0mg (2 products)
This product: 500mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 500mg

Other Ingredients

Gelatin

Label Claims — Verification

All Other
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take one to three capsules daily.

⚠️ Warnings & Precautions

Caution: If you are allergic to shellfish, please consult your health care professional before taking this product.

Keep out of reach of children

🧪 Formulation Notes

Made in the USA

MSM/Glucosamine Methylsulfonyl-methane with glucosamine MSM 500 mg Glucosamine 500 mg

Potency of MSM verified by GNC procedure #5405. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

No sugar, no starch, no artificial colors, no artificial flavors, sodium free, no wheat, no gluten, no corn, no soy, no dairy, yeast free.

Lignisul MSM

Additional Information

For more information: 1-888-462-2548

Store in a cool, dry place.

Product Details

UPC / SKU 0 48107 04887 7
DSLD Entry Date 2023-07-18
Product Type Non-Nutrient/Non-Botanical
Form Capsule
Brand GNC
DSLD ID 288677
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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