🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Softgel(s) Serving Size
63 Servings
Vitamin Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

5000 mcg (16667% DV)
📊 166.7× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 5.0mg

Other Ingredients

Soybean Oil Gelatin Glycerin yellow Beeswax Water Rapeseed Lecithin Colors added

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (100% of products) Structure/Function (91% of products) Nutrient (57% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Adults, consult your physician before use. Take 1 softgel daily with water and a meal.

⚠️ Warnings & Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing. Caution: Do not exceed 1 softgel daily unless recommended by your physician. Biotin may interfere with lab tests.

If you are taking medication or planning to undergo lab testing, consult your physician before use.

🧪 Formulation Notes

May help support healthy hair, skin and nails For those diagnosed with very low levels of biotin

Maximum 5,000 mcg - For adults deficient in biotin, as diagnosed by their physician using appropriate biomarkers.

No synthetic dyes - colors derived from natural sources No artificial flavors Gluten free

USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org.

Additional Information

25% more free #1 pharmacist recommended Vitamin & supplement brand

USP Dietary Supplement Verified

Based on Pharmacy Times Survey of pharmacists recommending Letter Vitamin Supplements.

Product Details

UPC / SKU 0 31604 02936 4
DSLD Entry Date 2023-06-22
Product Type Vitamin
Form Softgel Capsule
Brand Nature Made
DSLD ID 287807
Data Updated 2026-04-11

Research Evidence

31 Research Sources
53 Avg Quality Score
12 Meta Analysis
9 Systematic Review
5 Rct
2 Clinical Trial
1 Regulatory Source
1 Openfda Safety
B Pentasaccharides for the treatment of deep vein thrombosis
Meta Analysis The Cochrane database of systematic reviews 2017
B Quantitative comparison of the efficacy of clinical drug treatments for primary progressive multiple sclerosis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2023
B Dietary interventions for multiple sclerosis-related outcomes
Meta Analysis The Cochrane database of systematic reviews 2020
B Interventions for infantile seborrhoeic dermatitis (including cradle cap)
Meta Analysis The Cochrane database of systematic reviews 2019
B Effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis
Meta Analysis Fertility and sterility 2021
B Effect of feeding biotin on milk production and hoof health in lactating dairy cows: a quantitative assessment
Meta Analysis Journal of dairy science 2011
B Factitious Graves' Disease Due to Biotin Immunoassay Interference-A Case and Review of the Literature
Systematic Review The Journal of clinical endocrinology and metabolism 2016
B Effect of biotin on milk performance of dairy cattle: a meta-analysis
Meta Analysis Journal of dairy science 2011
B PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression-A Randomized Controlled Trial
Rct Nutrients 2020
B High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials
Meta Analysis Multiple sclerosis and related disorders 2021
View all evidence for Biotin →

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