5-HTP

product on market Capsule NutraKey Health Performance Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP is a precursor to serotonin and is supported by moderate evidence for its role in managing depressive symptoms and improving sleep quality. However, overall evidence coverage for this specific formulation is limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Gelatin Rice Flour
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommended Use: Take 1 serving (1 capsule) with water or your favorite beverage twice daily on an empty stomach or with food. Take first dose in the morning and second dose mid-day or evening depending on preference.

Warnings & Precautions

Warning: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.

Do not use if seal is broken.

Formulation Notes

Support healthy serotonin levels & enhanced mood

5-Hydroxytryptophan (5-HTP) is a chemical that the body makes from tryptophan, an essential amino acid that you get from the diet. After tryptophan is converted into 5-HTP, the chemical is then changed into another chemical called serotonin, a neurotransmitter, which relays signals between brain cells.

Enhance sleep & reduce appetite

Serotonin helps regulate mood and behavior, meaning 5-HTP may have a positive effect on sleep, mood, anxiety, appetite, and pain sensation. Some doctors consider 5-HTP to be the best natural appetite suppressant. 5-HTP is the immediate nutrient precursor to the neurotransmitter serotonin, also known as 5-HT (5-hydroxytryptamine). Serotonin has many profoundly important functions including a role in sleep, appetite, memory, learning, temperature regulation, mood, sexual behavior, cardiovascular function, muscle contraction, and endocrine regulation.

5-HTP is not found in the foods we eat, although tryptophan is. Eating foods with tryptophan does not significantly increase 6-HTP levels.

High-Performance Liquid Chromatography (HPLC) Verified

Mental performance

Ultra pure ingredients

Ultra micronized Max bioavailability

Improves well-being Support healthy serotonin levels Reduce stress & anxiety Improve brain function

Pharmaceutical grade

Increase sense of well-being Suppress appetite Reduce stress & anxiety Enhance sleep cycle Improve brain function Boost energy levels

Additional Information

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Made in the USA

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Metadata

Product Details

UPC / SKU8 20103 30974 5
DSLD Entry Date2023-06-22
Product TypeAmino acid/Protein
FormCapsule
DSLD ID287378
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.