🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Vegetarian Capsule(s) Serving Size
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)
This product: 500mg

Other Ingredients

Vegetarian Capsule Silicon Dioxide Microcrystalline Cellulose Silica Magnesium Stearate Magnesium Silicate

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (89% of products) Nutrient (7% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested Usage: 1 cello pack per day or as directed by a health professional.

⚠️ Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

🧪 Formulation Notes

Comprehensive support for your head brain, gut brain & heart brain Powerful full-nutrient supplement kit

Curcumin 500 mg

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Suitable for vegetarians/vegans.

Comprehensive support for optimal normal cognitive health Overall healthy mind support Addresses physical and mental fatigue Promotes sleep quality Supports gastrointestinal health Maintains heart health

Three Brains is a line of supplements designed to support the critical relationship between our head, heart, and gut. Together, these three "brains" influence our cognition and support a healthy mind. 3 Brains Total takes the guesswork out of supporting three brain health. Each convenient daily cello pack includes a combination of five important supplements that support brain and cognitive function, as well as cardiovascular and intestinal/gastrointestinal health. Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada.

Additional Information

A whole-body approach to maintaining balanced brain health and well-being Most of us tend to think of the brain as an isolated control center for all our other organs. But the fact is, our inner workings are far more synergistic. According to Karen Jensen, naturopathic doctor and author of Three Brains, there is a growing body of evidence to suggest that we actually have three "brains" and that their interaction influences our overall health. Dr. Jensen suggests, "nutrients from whole foods, exercise, and supplements are effective, non-invasive ways to support the 'three brains' interactions - optimize cognition and support a healthy mind." According to Karen Jensen, in her book: Three Brains: How the Heart, Brain, and Gut Influence Mental Health and Identity. Gut Directly engaged with the world Instinct and intuition / unselfconscious immediate / practical and direct Head Observing the world Inner life of logic / reasoning detailed future plans Heart Reaching out to the world Inner life of emotions / memories / images / visions / dreams

For freshness, store in a cool, dry place. No refrigeration required.

Recyclable container and label.

Product Details

DSLD Entry Date 2023-01-23
Product Type Other Combinations
Form Capsule
Bundle 3 Brains Total
DSLD ID 282116
Data Updated 2026-04-11

Research Evidence

311 Research Sources
54 Avg Quality Score
121 Systematic Review
98 Meta Analysis
70 Rct
16 Clinical Trial
2 Other
1 Narrative Review
1 Openfda Safety
A The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis
Meta Analysis Bioscience reports 2021
B Curcumin for depression: a meta-analysis
Meta Analysis Critical reviews in food science and nutrition 2020
B Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2024
B Complementary and Alternative Medicine Therapies for Psoriasis: A Systematic Review
Meta Analysis JAMA dermatology 2018
B Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review
Systematic Review Critical reviews in food science and nutrition 2022
B Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2024
B The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis
Meta Analysis Complementary therapies in medicine 2021
B Efficacy of Curcumin-Mediated Antimicrobial Photodynamic Therapy on Candida spp.-A Systematic Review
Systematic Review International journal of molecular sciences 2024
B Effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials
Meta Analysis BMC complementary medicine and therapies 2025
B Natural Products in Alzheimer's Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms
Systematic Review International journal of molecular sciences 2025
View all evidence for Curcumin →

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