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OPC Grape Seed Extract

product on market Capsule WholeHealth Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Grape seed, skin, and red wine extracts provide oligomeric proanthocyanidins, which are researched for their antioxidant and cardiovascular support properties. Evidence for these effects is generally moderate, though clinical data for specific health claims remains limited. The ingredient profile maintains a high safety rating.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for OPC Grape Seed Extract
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
90
Servings
Botanical
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
Grape skin extract
100 mg
Red Wine Grape Extract
60 mg

Other Ingredients

Microcrystalline Cellulose HPMC Water Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement, adults take two capsules once or twice daily with water, or as recommended by a health care practitioner.

Warnings & Precautions

Consult your health care practitioner prior to use and inform your pharmacist of all dietary supplements you are taking.

Keep out of reach of children.

Do not use if outer seal is broken or missing.

Formulation Notes

OPC grape seed extract 95% proanthocyanidins

Vegan/vegetarian product

Does not contain: Milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, or soybeans.

Made in the U.S.A. using the highest quality ingredients carefully sourced from around the world. Lab-assayed for purity.

Additional Information

Store tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU8 36485 00099 6
DSLD Entry Date2022-11-22
Product TypeBotanical
FormCapsule
BrandWholeHealth
DSLD ID276493
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
9
Rct
2
Meta Analysis
2
Clinical Trial
1
Systematic Review
B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial
Rct Nutrients 2023 PubMed DOI
B Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature
Systematic Review Nutrients 2021 PubMed DOI
B The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials
Meta Analysis Journal of the American Dietetic Association 2011 PubMed DOI
B The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
Meta Analysis Medicine 2016 PubMed DOI
B Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers
Rct Nutrients 2021 PubMed DOI
C Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Rct The British journal of nutrition 2016 PubMed DOI
C Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Rct Metabolism: clinical and experimental 2009 PubMed DOI
C Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial
Rct Phytotherapy research : PTR 2021 PubMed DOI
C The effect of polyphenol-rich chardonnay seed supplements on peripheral endothelial function.
Rct European journal of nutrition PubMed DOI
C The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.
Rct BMC complementary medicine and therapies PubMed DOI
View all evidence for Grape Seed →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.