🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Label Data

2 Tablet(s) Serving Size
187 Servings
Non-Nutrient/Non-Botanical Product Type
25% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s) (1% DV)
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
Methyl Sulfonyl Methane
1500 mg

Other Ingredients

Glucosamine Hydrochloride Methylsulfonylmethane Microcrystalline Cellulose Hydroxypropyl Methylcellulose Carnauba Wax Croscamellose Sodium Crospovidone Magnesium Stearate Polyethylene Glycol Silica Stearic Acid

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Two tablets per day

When to take Anytime Take two tablets once a day Suggested Use: Adults take two (2) tablets once a day, or as directed by a physician.

⚠️ Warnings & Precautions

Contains: Crustacean shellfish (crab, shrimp).

Keep out of the reach of children.

Caution: Pregnant or nursing women, individuals taking medication(s) or persons who have a health condition should consult their physician before using this product.

🧪 Formulation Notes

Cushions joints and supports movement Helps promote healthy cartilage

Kirkland Signature Extra Strength Glucosamine HCI with MSM may help support flexibility, range of motion and joint function Benefits of Kirkland Signature Glucosamine HCI with MSM Dietary Supplement: Cushions joints and supports movement Helps promote healthy cartilage

2 tablets a day provide: 1500 mg of Glucosamine HCI 1500 mg of MSM

No artificial colors or flavors No gluten No lactose

Tablet color may vary.

This item is verified by the United States Pharmacopeia (USP) which is an independent, scientific, non-profit organization that sets strict quality and purity standards for dietary supplements manufactured and distributed worldwide. The USP's drug standards are enforceable in the United States by the Food and Drug Administration.

Additional Information

USP Verified Dietary Supplement

Store at 15 degrees - 30 degrees C (59 degrees - 86 degrees F).

Since 1995, the Kirkland Signature brand has been providing high quality supplements at a great member value. Kirkland Signature vitamins, minerals, and supplements are made from carefully selected ingredients from trusted suppliers. The supplements are manufactured in accordance with the Good Manufacturing Practice standards. Additionally, many of the items are verified by the United States Pharmacopeia (USP) which is an independent, scientific, non-profit organization that sets strict quality and purity standards for dietary supplements.

Product Details

DSLD Entry Date 2022-08-23
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 275999
Data Updated 2026-04-11

Research Evidence

39 Research Sources
50 Avg Quality Score
20 Rct
9 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Regulatory Source
1 Openfda Safety
B Interventions for the management of temporomandibular joint osteoarthritis
Systematic Review The Cochrane database of systematic reviews 2012
B Glucosamine therapy for treating osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2005
B Chondroitin for osteoarthritis
Meta Analysis The Cochrane database of systematic reviews 2015
B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Meta Analysis Archives of orthopaedic and trauma surgery 2023
B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Rct The New England journal of medicine 2006
B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review
Systematic Review International journal of molecular sciences 2023
B Scientific Opinion on glucosamine and joint health
Regulatory Source EFSA Journal 2009
B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Meta Analysis Computational and mathematical methods in medicine 2022
B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Rct Annals of the rheumatic diseases 2016
B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
Meta Analysis Journal of orthopaedic surgery and research 2018
View all evidence for Glucosamine →

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