🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
90 Servings
Amino acid/Protein Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

50 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 50mg

Other Ingredients

Rice Flour Hypromellose

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1 capsule daily, preferably on an empty stomach at bedtime.

⚠️ Warnings & Precautions

Caution: For adults only.

Not recommended for pregnant/nursing women. Consult a physician if taking medications (especially antidepressants), or have a medical condition.

May cause drowsiness and mild transient GI symptoms. Take with food in case of GI upset.

Keep out of reach of children.

To report a serious adverse event, or for product information, contact 1-800-234-8686

🧪 Formulation Notes

5-HTP, the intermediate metabolite between the amino acid tryptophan and serotonin, is extracted from the seed of an African plant (Griffonia simplicfolia).

Natural color variation may occur in this product.

5-HTP 50 mg natural source

Supports positive mood

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens. Non-GMO

Additional Information

Store in a cool, dry place after opening.

Product Details

DSLD Entry Date 2022-10-24
Product Type Amino acid/Protein
Form Capsule
DSLD ID 275189
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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