NMN 12000 400 mg by Doctor's Best — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Beta-Nicotinamide Mononucleotide: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

This product received a low safety score because the 400mg dose of Beta-Nicotinamide Mononucleotide is more than 11 times higher than the recommended maximum daily limit.

Label Data

2 Veggie Capsule(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Beta-Nicotinamide Mononucleotide

400 mg

⚠️ Exceeds Tolerable Upper Intake Level by 11.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 400mg UL 35mg

Other Ingredients

Rice Flour Hypromellose Magnesium Stearate Silicon Dioxide Pectin

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (90% of products) Nutrient (2% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Adult Use: Take 2 capsules daily.

⚠️ Warnings & Precautions

Warning: Not recommended for children.

Consult a physician before use if you are pregnant, nursing, have a medical condition or taking any medications.

Keep out of reach of children.

🧪 Formulation Notes

Nicotinamide Mononucleotide (NMN) is the precursor to Nicotinamide Adenine Dinucleotide (NAD+), an essential component of the cellular processes to support various metabolic functions. As we age, NAD+ levels decline in the body, decreasing the mitochondrial sirtuins which may play a role in healthy aging.

400 mg per serving

Supports healthy aging, energy, and NAD+ production

Supports Healthy aging and NAD+ production Stimulates energy production Metabolic functions

Additional Information

Store in a cool fry place.

Made in the USA

Product Details

UPC / SKU 7 53950 00577 8

DSLD Entry Date 2022-06-16

Product Type Non-Nutrient/Non-Botanical

Form Capsule

Brand Doctor's Best

DSLD ID 270688

Data Updated 2026-04-11

Research Evidence

8 Research Sources

54 Avg Quality Score

4 Rct

2 Meta Analysis

2 Clinical Trial

B Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2025

PubMed DOI

B Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study

Rct GeroScience 2024

PubMed DOI

C Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.

Rct Science (New York, N.Y.)

PubMed DOI

C The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.

Rct GeroScience

PubMed DOI

C Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials

Meta Analysis Current diabetes reports 2024

PubMed DOI

C Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial

Rct Scientific reports 2023

PubMed DOI

C Safety and Pharmacokinetics of Nicotinamide Mononucleotide (NMN) in Healthy Adults.

Clinical Trial ClinicalTrials.gov 2021

ClinicalTrials.gov

C Effect of 'Nicotinamide Mononucleotide' (NMN) on Cardiometabolic Function

Clinical Trial ClinicalTrials.gov 2017

ClinicalTrials.gov

View all evidence for Nmn →