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5-HTP 100 mg

product on market Capsule Best Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-Hydroxytryptophan serves as a precursor to serotonin and is researched for its role in supporting mood and sleep. There is moderate evidence suggesting its efficacy in managing depressive symptoms. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
120
Servings
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Rice Flour Capsule
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, take one (1) capsule one to three times daily preferably on empty stomach at bedtime. Consider taking this product in combination with Best Naturals Valerian Root, Relora and Pantothenic Acid.

Warnings & Precautions

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Formulation Notes

5-HTP is a drug-free plant-derived source of an amino acid from the seeds of Griffonia simplicifolia plant that naturally increases the body's level of serotonin, the chemical messenger that affects emotions, behavior, appetite, thought and sleep. Certain research publications indicate that 5-HTP may help support the following: Supports relaxation and restful sleep. Supports appetite control. Supports positive mood.

5-Hydroxytryptophan

Premium formula

3rd party lab tested

No artificial color, flavor or sweetener, no preservatives, no sugar, no milk, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

Additional Information

Keep in cool, dry place.

Made in USA

GMP Good Manufacturing Practice Product

For additional information call: 1-877-659-6004

Metadata

Product Details

UPC / SKU8 17716 01219 3
DSLD Entry Date2022-06-16
Product TypeAmino acid/Protein
FormCapsule
DSLD ID270282
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.