Berberine Complex by Integrative Therapeutics — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
50% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

2 Capsule(s) Serving Size

45 Servings

Botanical Product Type

50% Evidence Coverage

Supplement Facts — Evidence Check

Total Carbohydrates

1 Gram(s) (1% DV)

Barberry (Berberis vulgaris) root extract

400 mg

📊 Market median: 500.0mg (234 products) 📚 95 studies (Tier A: 0, B: 35)

This product: 400mg

Oregon Grape (Berberis aquifolium) root and stem extract

400 mg

📊 Market median: 500.0mg (234 products) 📚 95 studies (Tier A: 0, B: 35)

This product: 400mg

Goldenseal (Hydrastis canadensis) root and rhizome extract

100 mg

Other Ingredients

plant-derived Capsule Cellulose Magnesium Stearate Silicon Dioxide

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (86% of products) Nutrient (4% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Recommendation: Take 2 capsules three times daily, or as recommended by a healthcare professional.

⚠️ Warnings & Precautions

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Warning: Do not use this product if you are pregnant or nursing. If you have diabetes or if you are taking prescription drugs, consult a healthcare professional before use.

🧪 Formulation Notes

Vegan

Contains no wheat, gluten, soy, dairy, or artificial colors, flavors, or preservatives.

Intestinal support

Additional Information

For more information, please visit integrativepro.com

Keep tightly closed. Store at room temperature. Avoid excessive heat or direct sunlight.

Quality Global Sourcing Bottled & Tested in the USA

Product Details

UPC / SKU 8 71791 00085 8

DSLD Entry Date 2022-07-21

Product Type Botanical

Form Capsule

Brand Integrative Therapeutics

DSLD ID 269867

Data Updated 2026-04-11

Research Evidence

98 Research Sources

55 Avg Quality Score

48 Systematic Review

39 Meta Analysis

4 Rct

4 Clinical Trial

1 Other

1 Narrative Review

1 Openfda Safety

B Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2018

PubMed DOI

B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2022

PubMed DOI

B Efficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Phytomedicine : international journal of phytotherapy and phytopharmacology 2023

PubMed DOI

B Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2019

PubMed DOI

B Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis The Journal of nutrition 2023

PubMed DOI

B The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Meta Analysis Journal of translational medicine 2024

PubMed DOI

B Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease-Clinical and Pre-Clinical Overview and Systematic Review of the Literature

Systematic Review International journal of molecular sciences 2024

PubMed DOI

B Efficacy and Safety of Berberine Alone or Combined with Statins for the Treatment of Hyperlipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Meta Analysis The American journal of Chinese medicine 2019

PubMed DOI

B Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies

Meta Analysis International journal of molecular sciences 2023

PubMed DOI

B Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial

Rct JAMA network open 2025

PubMed DOI

View all evidence for Berberine →