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Double-Strength SAM-e 400 mg

product on market Tablet or Pill Doctor's Best Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade
Label

Product Label

Label for Double-Strength SAM-e 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Microcrystalline Cellulose Magnesium Silicate Stearic Acid Magnesium Stearate Flake Shellac dewaxed Magnesium Hydroxide Glycerol Silica Arginine Sodium Alginate Calcium Oxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Adult Use: Take 1 tablet daily between meals, or as recommended by a nutritionally informed physician. Do not chew or crush tablet.

Warnings & Precautions

Warning: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.

Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe.

Do not use if pregnant or nursing.

May cause gastrointestinal discomfort in a small percentage of people.

Formulation Notes

Helps support mood and neural function Helps support joint comfort and mobility Helps support liver health and detoxification

Vegetarian

Non-GMO Gluten free Soy free

Doctor’s Best SAM-e helps replenish your SAM-e levels and promote a healthy mood. SAM-e (S-Adenosyl-L-Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody. Supplementing with SAM-e Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate biochemical activity in the human body.

SAM-e and Mood and Cognitive Function SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body’s antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.

SAM-e and Joint Function In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.

SAM-e and Liver Function SAM-e helps support healthy levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e providing slow and targeted release for improved GI tolerance and absorption. Our Double-Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.

Additional Information

Store in a cool dry place.

Double Strength SAM-e is sealed in blister packs for freshness and stability.

Metadata

Product Details

UPC / SKU7 53950 00252 4
DSLD Entry Date2022-06-16
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID269568
Data Updated2026-04-11
Research

Research Evidence

We're building the evidence profile for this product's ingredients. Check back soon.

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.